Patients with ocular Hypertension: Higher polygenic Risk Score is associated with increased Risk of primary Open-angle Glaucoma

被引：0
|
作者：
Bitzer, Michaela
机构：
来源：
KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE | 2024年 / 241卷 / 07期
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D O I：
10.1055/a-2330-3341
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Primary open-angle glaucoma (POAG) is a largely hereditary disease for which 127 risk variants have been identified to date. While each individual variant plays a relatively minor role, they can be used together to measure the overall genetic load using a polygenic risk score (PRS). Genotyping can be carried out once at low cost and enables the calculation of a PRS for a wide range of diseases. The PRS can be calculated earlier in the life course, before environmental or phenotypic risk factors can have an impact.
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页码：803 / 803
页数：1
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