Design, synthesis and biological evaluation of aryl isoxazole incorporated pyrimidin-2-yl)oxazolo[4,5-b]pyridine derivatives as anticancer agents

被引：2
|
作者：
Shaik, Khasim Saheb [1 ]
Saritha, N. [1 ]
Reddy, G. Nagendra [2 ]
机构：
[1] JNTUA Coll Engn, Dept Chem, Kalikiri, Andhra Pradesh, India
[2] Koneru Lakshmaiah Educ Fdn, Dept Chem, Guntur, Andhra Pradesh, India
来源：
RESULTS IN CHEMISTRY | 2024年 / 9卷
关键词：
Benoxaprofen; Benzoxazole; Acivicin; Isoxazole and anticancer activity; COPPER(I)-CATALYZED SYNTHESIS; CYCLIZATION; ANALOGS; INHIBITORS; DISCOVERY; ALKYNES;
D O I：
10.1016/j.rechem.2024.101628
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new library of Aryl Isoxazole Incorporated Pyrimidin-2-yl)oxazolo[4,5-b]pyridine compounds 11a-j and their structures were characterized by analytical data. Further, the preliminary anticancer activity of the newly prepared compounds 11a-j was examined against four types of human cancer cell lines, breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by utilizing the MTT method. Most of the compounds displayed good to moderate activities as compared with the etoposide used as a positive control. Amon, five compounds 11a, 11b, 11h, 11i and 11j exhibited more potent activity than the positive control. Mainly, compound 11h displayed superior anticancer activity.
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页数：5
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