Design, synthesis and biological evaluation of aryl isoxazole incorporated pyrimidin-2-yl)oxazolo[4,5-b]pyridine derivatives as anticancer agents

被引：2

作者：

Shaik, Khasim Saheb ^{[1
]}

Saritha, N. ^{[1
]}

Reddy, G. Nagendra ^{[2
]}

机构：

[1] JNTUA Coll Engn, Dept Chem, Kalikiri, Andhra Pradesh, India

[2] Koneru Lakshmaiah Educ Fdn, Dept Chem, Guntur, Andhra Pradesh, India

来源：

RESULTS IN CHEMISTRY | 2024年 / 9卷

关键词：

Benoxaprofen; Benzoxazole; Acivicin; Isoxazole and anticancer activity; COPPER(I)-CATALYZED SYNTHESIS; CYCLIZATION; ANALOGS; INHIBITORS; DISCOVERY; ALKYNES;

D O I：

10.1016/j.rechem.2024.101628

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new library of Aryl Isoxazole Incorporated Pyrimidin-2-yl)oxazolo[4,5-b]pyridine compounds 11a-j and their structures were characterized by analytical data. Further, the preliminary anticancer activity of the newly prepared compounds 11a-j was examined against four types of human cancer cell lines, breast cancer (MCF-7), lung cancer (A549), colon cancer (Colo-205) and ovarian cancer (A2780) by utilizing the MTT method. Most of the compounds displayed good to moderate activities as compared with the etoposide used as a positive control. Amon, five compounds 11a, 11b, 11h, 11i and 11j exhibited more potent activity than the positive control. Mainly, compound 11h displayed superior anticancer activity.

引用

页数：5

共 50 条

[31] Design, synthesis and biological evaluation of novel 3H-imidazole [ 4,5-b] pyridine derivatives as selective mTOR inhibitors
Zhang, Lingzhi
Bu, Tantan
Bao, Xiaobo
Liang, Tingting
Ge, Yiran
Xu, Yungen
Zhu, Qihua
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2017, 27 (15) : 3395 - 3398
[32] Synthesis, Molecular Docking and Biological Properties of Novel Thiazolo [4,5-b] pyridine Derivatives
Chaban, Taras, I
Matiichuk, Yulia E.
Shyyka, Olga Ya
Chaban, Ihor G.
Ogurtsov, Volodymyr V.
Nektegayev, Ihor A.
Matiychuk, Vasyl S.
ACTA CHIMICA SLOVENICA, 2020, 67 (04) : 1035 - 1043
[33] Synthesis and properties of 2-(2-furyl)[1,3]oxazolo[4,5-b]pyridine
El'chaninov, M. M.
Aleksandrov, A. A.
Illenzeer, E. V.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY, 2014, 50 (12) : 1826 - 1828
[34] Synthesis and properties of 2-(2-furyl)[1,3]oxazolo[4,5-b]pyridine
M. M. El’chaninov
A. A. Aleksandrov
E. V. Illenzeer
Russian Journal of Organic Chemistry, 2014, 50 : 1826 - 1828
[35] Synthesis of alkoxyphthalimide derivatives of p-bis-(2-hydroxy-4-aryl-6-iminothiazolidino[4,5-b]pyrimidin-N6-yl)biphenyls
Singh, B
Baregama, LK
Sharma, R
Ahmed, M
Talesara, GL
JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2005, 82 (04) : 337 - 341
[36] IMIDAZO(4,5-B)PYRIDINE DERIVATIVES OF POTENTIAL TUBERCULOSTATIC ACTIVITY .2. SYNTHESIS AND BIOACTIVITY OF DESIGNED AND SOME OTHER 2-CYANOMETHYLIMIDAZO(4,5-B)PYRIDINE DERIVATIVES
BUKOWSKI, L
KALISZAN, R
ARCHIV DER PHARMAZIE, 1991, 324 (09) : 537 - 542
[37] REGIOSELECTIVE SYNTHESIS OF 4-OXOBUTYLOXAZOLO[4,5-B]PYRIDINE-2-ONES AND 3-OXOBUTYLOXAZOLO[4,5-B]PYRIDINE-2-ONES AND THEIR DERIVATIVES
PESHAKOVA, L
KALCHEVA, V
JOURNAL FUR PRAKTISCHE CHEMIE, 1991, 333 (01): : 183 - 186
[38] Design, synthesis and biological evaluation of 3,5-diaryl isoxazole derivatives as potential anticancer agents
Aktas, Derya Anil
Akinalp, Gokcen
Sanli, Fatma
Yucel, Mehmet Ali
Gambacorta, Nicola
Nicolotti, Orazio
Karatas, Omer Faruk
Algul, Oztekin
Burmaoglu, Serdar
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2020, 30 (19)
[39] Synthesis and Biological Activities of Novel 1H-Imidazo[4,5-b]pyridine Derivatives
Jebamani, Jesurajan
Praneshm, Shubha Jayachamarajapura
Shivalingappa, Jayadev
Narayanarao, Manjunatha
Pasha, Mussuvir
Pawar, Chandrakant
CHEMISTRYSELECT, 2023, 8 (28):
[40] Design, Synthesis, and Biological Evaluation of 1,2,4-Oxadiazole-Isoxazole Linked Quinazoline Derivatives as Anticancer Agents
M. Srinivas
S. Satyaveni
B. Ram
Russian Journal of General Chemistry, 2019, 89 : 2492 - 2497

← 1 2 3 4 5 →