Digital light processing (DLP) 3D printing of polymer networks comprising virus-like particles

被引:1
|
作者
Sadaba, Naroa [1 ]
Bayon, Jorge Leganes [2 ,3 ,4 ]
Nelson, Alshakim [1 ]
Steinmetz, Nicole F. [2 ,3 ,4 ,5 ,6 ,7 ,8 ]
机构
[1] Univ Washington, Dept Chem, Seattle, WA 98195 USA
[2] Univ Calif San Diego, Aiiso Yufeng Li Family Dept Chem & Nano Engn, 9500 Gilman Dr, La Jolla, CA 92093 USA
[3] Univ Calif San Diego, Dept Bioengn, 9500 Gilman Dr, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Dept Radiol, 9500 Gilman Dr, La Jolla, CA 92093 USA
[5] Univ Calif San Diego, Ctr Nanoimmunoengn, 9500 Gilman Dr, La Jolla, CA 92093 USA
[6] Univ Calif San Diego, Shu & K C Chien & Peter Farrell Collaboratory, 9500 Gilman Dr, San Diego, CA 92093 USA
[7] Univ Calif San Diego, Inst Engn Med, Ctr Engn Canc, 9500 Gilman Dr, La Jolla, CA 92093 USA
[8] Univ Calif San Diego, Moores Canc Ctr, 9500 Gilman Dr, La Jolla, CA 92093 USA
关键词
3D printing - Addition reactions - Biopolymers - Polyethylene glycols - Viruses;
D O I
10.1039/d4cc02411g
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
In this work, we introduce a 3D-printable virus-like particle (VLP)-enhanced cross-linked biopolymer system. VLPs displaying surface-available acrylate groups were prepared through aza-Michael addition to serve as resins. The VLP resins were then photopolymerized into a poly(ethylene glycol) diacrylate (PEGDA) network following DLP 3D printing. This approach represents a convergence of disciplines, where the synergistic interaction between virology and additive manufacturing unlocks new frontiers in biotechnology. In this work, we introduce a 3D-printable virus-like particle (VLP)-enhanced cross-linked biopolymer system.
引用
收藏
页码:9733 / 9736
页数:5
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