Photoredox-Enabled Synthesis of α-Alkylated Alkenylammonium Salts

被引：0
|
作者：
Tonedachi, Rina [1 ]
Yoshita, Aoi [1 ]
Sakakibara, Yota [1 ]
Murakami, Kei [1 ,2 ]
机构：
[1] Kwansei Gakuin Univ, Sch Sci & Technol, Dept Chem, Gakuen Uegahara 1, Sanda, Hyogo 6691330, Japan
[2] JST PRESTO, 7 Gobancho,Chiyoda, Tokyo 1020076, Japan
来源：
SYNTHESIS-STUTTGART | 2024年 / 56卷 / 21期
基金：
日本科学技术振兴机构;
关键词：
alkenylammonium salts; photoredox catalyst; alkylation; halogen-atom transfer; quaternary ammonium salts; ATOM TRANSFER; RADICALS; GENERATION;
D O I：
10.1055/a-2302-5887
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The development of novel synthetic methods for quaternary ammonium salts is highly demanded since the current synthesis heavily relies on the conventional Menshutkin reaction. Herein, we report photoredox-catalyzed alkylation of alpha-brominated alkenylammonium salts. Mechanistically, the generation of a highly reactive alpha-ammoniovinyl radical is the key to our method. This reaction enables thesynthesis of various unprecedented alpha-alkylated alkenylammonium salts.
引用
收藏
页码：3341 / 3347
页数：7
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