REPEAT SEQUENCES IN THE GENE ENCODING THE HUMAN D4 DOPAMINE RECEPTOR

被引:6
|
作者
ODOWD, BF [1 ]
机构
[1] ADDICT RES FDN,TORONTO M5S 1A8,ONTARIO,CANADA
关键词
G-PROTEIN-COUPLED RECEPTORS; 3RD CYTOPLASMIC LOOP; PARALOG; INTRON EXON;
D O I
10.1016/0378-1119(92)90207-6
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The gene encoding the human D4 dopamine receptor has evolved by gaining at least five internal repeats which are located within exons 3 and 4, and in the intervening intron 3 sequence. The amino acid sequence in the cytoplasmic loop of the receptor, involved in G protein coupling, has been altered by these gene changes.
引用
收藏
页码:301 / 302
页数:2
相关论文
共 50 条
  • [31] Urge for alcohol and the dopamine D4 receptor (DRD4) gene
    McGeary, John
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 2006, 30 (06) : 253A - 253A
  • [32] Temperament and character profiles and the dopamine D4 receptor gene in ADHD
    Lynn, DE
    Lubke, G
    Yang, M
    McCracken, JT
    McGough, JJ
    Ishii, J
    Loo, SK
    Nelson, SF
    Smalley, SL
    AMERICAN JOURNAL OF PSYCHIATRY, 2005, 162 (05): : 906 - 914
  • [33] Adult ADHD: Association with the dopamine D4 receptor gene.
    Muglia, P
    Jain, U
    Basile, VS
    Kennedy, JL
    AMERICAN JOURNAL OF HUMAN GENETICS, 1999, 65 (04) : A462 - A462
  • [34] D4 dopamine receptor gene polymorphisms and social behavior in ADHD
    Tarnok, Z
    Birkas, E
    Nemoda, Z
    Gadoros, J
    Sasvari, M
    Gervai, J
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2004, 130B (01): : 119 - 120
  • [35] Evidence for positive selection acting at the human dopamine receptor D4 gene locus.
    Moyzis, RL
    Ding, YC
    Chi, HC
    Grady, DL
    Kidd, JR
    Morishima, A
    Kidd, KK
    Flodman, P
    Spence, MA
    Schuck, S
    Swanson, JM
    Zhang, YP
    AMERICAN JOURNAL OF HUMAN GENETICS, 2001, 69 (04) : 228 - 228
  • [36] Dopamine D4 receptor gene and attention deficit hyperactivity disorder
    Frank, Y
    Pergolizzi, RG
    Perilla, MJ
    PEDIATRIC NEUROLOGY, 2004, 31 (05) : 345 - 348
  • [37] ASSOCIATION STUDY BETWEEN THE DOPAMINE D4 RECEPTOR GENE AND SCHIZOPHRENIA
    PETRONIS, A
    MACCIARDI, F
    ATHANASSIADES, A
    PATERSON, AD
    VERGA, M
    MELTZER, HY
    COLA, P
    BUCHANAN, JA
    VANTOL, HHM
    KENNEDY, JL
    AMERICAN JOURNAL OF MEDICAL GENETICS, 1995, 60 (05): : 452 - 455
  • [38] Dopamine D4 receptor gene polymorphisms and neuroleptic response in schizophrenia
    Hwu, HG
    Hong, CJ
    Lee, YL
    Lee, PC
    Lee, SFC
    BIOLOGICAL PSYCHIATRY, 1998, 44 (06) : 483 - 487
  • [39] Polymorphic variation in the D4 dopamine receptor gene and novelty seeking
    Gelernter, J
    Kranzler, H
    Coccaro, E
    New, A
    Siever, LJ
    Mulgrew, C
    BIOLOGICAL PSYCHIATRY, 1997, 41 : 183 - 183
  • [40] Lack of association between dopamine D4 receptor gene and schizophrenia
    Tanaka, T
    Igarashi, S
    Onodera, O
    Tanaka, H
    Kameda, K
    Takahashi, K
    Tsuji, S
    Ihda, S
    AMERICAN JOURNAL OF MEDICAL GENETICS, 1995, 60 (06): : 580 - 582