MORPHOLOGICAL CHANGES OF SENSORIMOTOR CORTEX AND HIPPOCAMPUS IN RATS OF DIFFERENT AGE AFTER TRAUMATIC BRAIN INJURY

被引：0
|
作者：
Mikhalsky, S. A. [1 ]
Savitska, D., V [1 ]
Biloshytsky, V. V. [1 ]
Kvitnitskaya-Ryzhova, T. Yu [1 ]
机构：
[1] State Univ, Inst Gerontol DF Chebotareva NAMS Ukraine, Inst Duma Neurosurg AP Romodanov NAMS Ukraine, Kiev, Ukraine
来源：
WORLD OF MEDICINE AND BIOLOGY | 2014年 / 46卷 / 04期
关键词：
traumatic brain injury; gene therapy; cortex; hippocampus; structural changes; morphometry; age characteristics;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In the model of severe traumatic brain injury (TBI) in adult and old Wistar rats we have demonstrated significant changes in the structure of sensorimotor cortex and hippocampus, resulting in a significant decrease in the number of neurons, growth of vacuolated hyperchromic nerve cells fraction and the sharp increase in the number of glia. Gene therapy by means of cationic liposome-mediated APOE3 transfer significantly decreased reactive gliosis and number of microgliocytes both in the cortex and in the hippocampus, and had a positive effect on the number of neurons, preventing their loss in adult and especially in old rats.
引用
收藏
页码：120 / 126
页数：8
相关论文
共 50 条
  • [41] Traumatic Brain Injury and Neuronal Functionality Changes in Sensory Cortex
    Carron, Simone F.
    Alwis, Dasuni S.
    Rajan, Ramesh
    FRONTIERS IN SYSTEMS NEUROSCIENCE, 2016, 10
  • [42] Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
    Braeckman, Kim
    Descamps, Benedicte
    Vanhove, Christian
    JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2019, (150):
  • [43] Transcriptional changes in the mouse cortex following traumatic brain injury
    Israelsson, C
    Lewén, A
    Kylberg, A
    Hillered, L
    Ebendal, T
    JOURNAL OF NEUROTRAUMA, 2005, 22 (10) : 1181 - 1181
  • [44] TIME-COURSE OF SENSORIMOTOR BRAIN ACTIVATION AFTER TRAUMATIC BRAIN INJURY IN THE RAT
    Verley, Derek
    Hovda, David
    Sutton, Richard
    Harris, Neil
    JOURNAL OF NEUROTRAUMA, 2011, 28 (06) : A81 - A81
  • [45] Integrated Bioinformatics Analysis for the Identification of Key Molecules and Pathways in the Hippocampus of Rats After Traumatic Brain Injury
    Xiao, Xiao
    Bai, Peng
    Cao, Shuqiang
    Jiang, Youjing
    Liang, Weibo
    Wang, Tao
    Luo, Xiaolei
    Guan, Qiaozhi
    Gao, Linbo
    Zhang, Lin
    NEUROCHEMICAL RESEARCH, 2020, 45 (04) : 928 - 939
  • [46] Integrated Bioinformatics Analysis for the Identification of Key Molecules and Pathways in the Hippocampus of Rats After Traumatic Brain Injury
    Xiao Xiao
    Peng Bai
    Shuqiang Cao
    Youjing Jiang
    Weibo Liang
    Tao Wang
    Xiaolei Luo
    Qiaozhi Guan
    Linbo Gao
    Lin Zhang
    Neurochemical Research, 2020, 45 : 928 - 939
  • [47] Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury
    Chen, Zhihao
    Wang, Hong
    Zhong, Jianjun
    Yang, Junqing
    Darwazeh, Rami
    Tian, Xiaocui
    Huang, Zhijian
    Jiang, Li
    Cheng, Chongjie
    Wu, Yue
    Guo, Zongduo
    Sun, Xiaochuan
    EXPERIMENTAL NEUROLOGY, 2019, 313 : 37 - 48
  • [48] AGE-DEPENDENT CHANGES IN CEREBRAL HEMODYNAMICS AFTER MILD TRAUMATIC BRAIN INJURY
    Thibeault, Corey
    Canac, Nicolas
    Radhakrishnan, Shankar
    LeVangie, James
    Sheridan, Chris
    Brown, Anne
    Kim, Yena
    Rafie, Daniel
    Giza, Christopher
    Hamilton, Robert
    Choe, Meeryo
    JOURNAL OF NEUROTRAUMA, 2021, 38 (14) : A90 - A90
  • [49] Association of Chronic Vascular Changes with Functional Outcome after Traumatic Brain Injury in Rats
    Hayward, Nick M. E. A.
    Immonen, Riikka
    Tuunanen, Pasi I.
    Ndode-Ekane, Xavier Ekolle
    Grohn, Olli
    Pitkanen, Asla
    JOURNAL OF NEUROTRAUMA, 2010, 27 (12) : 2203 - 2219
  • [50] Changes in neuromedin S and its receptor after traumatic brain injury in cycling rats
    Khaksari, Mohammad
    Maghool, Fatemeh
    Asadikaram, Gholamreza
    Naderi, Vida
    NEUROLOGY ASIA, 2015, 20 (04) : 375 - 384
12345