MORPHOLOGICAL CHANGES OF SENSORIMOTOR CORTEX AND HIPPOCAMPUS IN RATS OF DIFFERENT AGE AFTER TRAUMATIC BRAIN INJURY

被引：0
|
作者：
Mikhalsky, S. A. [1 ]
Savitska, D., V [1 ]
Biloshytsky, V. V. [1 ]
Kvitnitskaya-Ryzhova, T. Yu [1 ]
机构：
[1] State Univ, Inst Gerontol DF Chebotareva NAMS Ukraine, Inst Duma Neurosurg AP Romodanov NAMS Ukraine, Kiev, Ukraine
来源：
WORLD OF MEDICINE AND BIOLOGY | 2014年 / 46卷 / 04期
关键词：
traumatic brain injury; gene therapy; cortex; hippocampus; structural changes; morphometry; age characteristics;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
In the model of severe traumatic brain injury (TBI) in adult and old Wistar rats we have demonstrated significant changes in the structure of sensorimotor cortex and hippocampus, resulting in a significant decrease in the number of neurons, growth of vacuolated hyperchromic nerve cells fraction and the sharp increase in the number of glia. Gene therapy by means of cationic liposome-mediated APOE3 transfer significantly decreased reactive gliosis and number of microgliocytes both in the cortex and in the hippocampus, and had a positive effect on the number of neurons, preventing their loss in adult and especially in old rats.
引用
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页码：120 / 126
页数：8
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