MORPHOLOGICAL CHANGES OF SENSORIMOTOR CORTEX AND HIPPOCAMPUS IN RATS OF DIFFERENT AGE AFTER TRAUMATIC BRAIN INJURY

被引：0

作者：

Mikhalsky, S. A. ^{[1
]}

Savitska, D., V ^{[1
]}

Biloshytsky, V. V. ^{[1
]}

Kvitnitskaya-Ryzhova, T. Yu ^{[1
]}

机构：

[1] State Univ, Inst Gerontol DF Chebotareva NAMS Ukraine, Inst Duma Neurosurg AP Romodanov NAMS Ukraine, Kiev, Ukraine

来源：

WORLD OF MEDICINE AND BIOLOGY | 2014年 / 46卷 / 04期

关键词：

traumatic brain injury; gene therapy; cortex; hippocampus; structural changes; morphometry; age characteristics;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

In the model of severe traumatic brain injury (TBI) in adult and old Wistar rats we have demonstrated significant changes in the structure of sensorimotor cortex and hippocampus, resulting in a significant decrease in the number of neurons, growth of vacuolated hyperchromic nerve cells fraction and the sharp increase in the number of glia. Gene therapy by means of cationic liposome-mediated APOE3 transfer significantly decreased reactive gliosis and number of microgliocytes both in the cortex and in the hippocampus, and had a positive effect on the number of neurons, preventing their loss in adult and especially in old rats.

引用

页码：120 / 126

页数：8

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