SERUM LEVELS OF AMINOTERMINAL TYPE-III PROCOLLAGEN PEPTIDE AND HYALURONAN PREDICT MORTALITY IN SYSTEMIC-SCLEROSIS

被引：30

作者：

SCHEJA, A ^{[1
]}

AKESSON, A ^{[1
]}

HORSLEVPETERSEN, K ^{[1
]}

机构：

[1] HVIDOVRE UNIV HOSP, DEPT RHEUMATOL, DK-2650 HVIDOVRE, DENMARK

来源：

SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 1992年 / 21卷 / 01期

关键词：

SYSTEMIC SCLEROSIS; SCLERODERMA; COLLAGEN; COLLAGEN PROPEPTIDE; HYALURONAN;

D O I：

10.3109/03009749209095054

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Systemic sclerosis (SSc) is characterized by an excessive accumulation of collagen in skin and internal organs and increased serum concentrations of different connective tissue metabolites have been reported. In this study of 82 patients with SSc, serum concentrations of aminoterminal type III procollagen peptide (PIIINP), smaller PIIINP-related antigens (Fab PIIINP) and hyaluronan (HA) were increased as compared to healthy controls matched for age and sex. Patients with a shorter disease duration (< 3 years) had higher serum levels of PIIINP and Fab PIIINP than patients with a longer disease duration. The highest serum concentrations of PIIINP and HA were seen in seven patients who died within 2 years.

引用

页码：5 / 9

页数：5

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