SERUM LEVELS OF AMINOTERMINAL TYPE-III PROCOLLAGEN PEPTIDE AND HYALURONAN PREDICT MORTALITY IN SYSTEMIC-SCLEROSIS

被引：30
|
作者：
SCHEJA, A [1 ]
AKESSON, A [1 ]
HORSLEVPETERSEN, K [1 ]
机构：
[1] HVIDOVRE UNIV HOSP, DEPT RHEUMATOL, DK-2650 HVIDOVRE, DENMARK
来源：
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY | 1992年 / 21卷 / 01期
关键词：
SYSTEMIC SCLEROSIS; SCLERODERMA; COLLAGEN; COLLAGEN PROPEPTIDE; HYALURONAN;
D O I：
10.3109/03009749209095054
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Systemic sclerosis (SSc) is characterized by an excessive accumulation of collagen in skin and internal organs and increased serum concentrations of different connective tissue metabolites have been reported. In this study of 82 patients with SSc, serum concentrations of aminoterminal type III procollagen peptide (PIIINP), smaller PIIINP-related antigens (Fab PIIINP) and hyaluronan (HA) were increased as compared to healthy controls matched for age and sex. Patients with a shorter disease duration (< 3 years) had higher serum levels of PIIINP and Fab PIIINP than patients with a longer disease duration. The highest serum concentrations of PIIINP and HA were seen in seven patients who died within 2 years.
引用
收藏
页码：5 / 9
页数：5
相关论文
共 50 条
  • [21] IS THE AMINOTERMINAL PROPEPTIDE OF TYPE-III PROCOLLAGEN DEGRADED IN THE LIVER - A STUDY OF TYPE-III PROCOLLAGEN PEPTIDE IN SERUM DURING LIVER-TRANSPLANTATION IN PIGS
    BENTSEN, KD
    BOESBY, S
    KIRKEGAARD, P
    HANSEN, CP
    JENSEN, SL
    HORSLEVPETERSEN, K
    LORENZEN, I
    JOURNAL OF HEPATOLOGY, 1988, 6 (02) : 144 - 150
  • [22] PRIMARY FIBROMYALGIA - CLINICAL-PARAMETERS IN RELATION TO SERUM PROCOLLAGEN TYPE-III AMINOTERMINAL PEPTIDE
    JACOBSEN, S
    JENSEN, LT
    FOLDAGER, M
    DANNESKIOLDSAMSOE, B
    BRITISH JOURNAL OF RHEUMATOLOGY, 1990, 29 (03): : 174 - 177
  • [23] SERUM AND URINE ANALYSIS OF THE AMINOTERMINAL PROCOLLAGEN PEPTIDE TYPE-III BY RADIOIMMUNOASSAY WITH ANTIBODY FAB FRAGMENTS
    ROHDE, H
    LANGER, I
    KRIEG, T
    TIMPL, R
    COLLAGEN AND RELATED RESEARCH, 1983, 3 (05): : 371 - 379
  • [24] SERUM CONCENTRATIONS OF PROCOLLAGEN TYPE-III AMINOTERMINAL PEPTIDE IN GROWING DOGS WITH HIP-DYSPLASIA
    MADSEN, JS
    SVALASTOGA, E
    JENSEN, LT
    ACTA VETERINARIA SCANDINAVICA, 1995, 36 (01) : 157 - 160
  • [25] HIGHER LEVELS OF SERUM AMINOTERMINAL TYPE-III PROCOLLAGEN PEPTIDE, AND LAMININ IN ALCOHOLIC THAN IN NONALCOHOLIC CIRRHOSIS OF EQUAL SEVERITY
    LOTTERER, E
    GRESSNER, AM
    KROPF, J
    GROBE, E
    VONKNEBEL, D
    BIRCHER, J
    JOURNAL OF HEPATOLOGY, 1992, 14 (01) : 71 - 77
  • [26] PREDICTIVE VALUE OF SERUM AMINOTERMINAL TYPE-III PROCOLLAGEN PEPTIDE LEVELS, SERUM LAMININ LEVELS, AND LIVER MEMBRANE ANTIBODIES FOR PROGNOSIS OF CHRONIC HEPATITIS
    HIRATA, R
    TANAKA, Y
    IZUMI, N
    HASUMURA, Y
    HEPATOLOGY, 1988, 8 (05) : 1418 - 1418
  • [27] SERUM AMINOTERMINAL TYPE-III PROCOLLAGEN PEPTIDE - RELATION TO BIOSYNTHESIS OF COLLAGEN TYPE-III IN EXPERIMENTALLY INDUCED GRANULATION-TISSUE IN RATS
    HORSLEVPETERSEN, K
    KIM, KY
    PEDERSEN, LR
    BENTSEN, KD
    ULDBJERG, N
    OXLUND, H
    GARBARSCH, C
    HAHN, EG
    SCHUPPAN, D
    LORENZEN, I
    APMIS, 1988, 96 (09) : 793 - 804
  • [28] THE CONCENTRATION PATTERN OF LAMININ, HYALURONAN, AND AMINOTERMINAL PROPEPTIDE OF TYPE-III PROCOLLAGEN IN SEMINAL FLUID
    GEIPEL, U
    KROPF, J
    KRAUSE, W
    GRESSNER, AM
    ANDROLOGIA, 1992, 24 (04) : 205 - 211
  • [29] SERUM LEVELS OF TYPE-III PROCOLLAGEN PEPTIDE IN DIABETES-MELLITUS
    TRIOLO, G
    GIARDINA, E
    ZARCONE, MR
    SEDDIO, G
    BOMPIANI, GD
    HORMONE AND METABOLIC RESEARCH, 1989, 21 (02) : 77 - 80
  • [30] SERUM AMINOTERMINAL TYPE-III PROCOLLAGEN PEPTIDE REFLECTS REPAIR AFTER ACUTE MYOCARDIAL-INFARCTION
    JENSEN, LT
    HORSLEVPETERSEN, K
    TOFT, P
    BENTSEN, KD
    GRANDE, P
    SIMONSEN, EE
    LORENZEN, I
    CIRCULATION, 1990, 81 (01) : 52 - 57
12345