SYNTHESIS, BIOLOGICAL PROPERTIES, AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF QUINOXALINE ANGIOTENSIN-II RECEPTOR ANTAGONISTS

被引：17
|
作者：
KIM, KS
QIAN, L
DICKINSON, KEJ
DELANEY, CL
BIRD, JE
WALDRON, TL
MORELAND, S
机构：
[1] The Bristol-Myers-Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(01)80738-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Quinoxaline heterocycle containing angiotensin II receptor antagonist analogs were prepared. All five analogs reported here display potent antagonistic activities and most interestingly, quinoxaline bis-N-oxide 10 exhibits very potent activities both in binding and functional assays.
引用
收藏
页码：2667 / 2670
页数：4
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