SYNTHESIS, BIOLOGICAL PROPERTIES, AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF QUINOXALINE ANGIOTENSIN-II RECEPTOR ANTAGONISTS

被引：17
|
作者：
KIM, KS
QIAN, L
DICKINSON, KEJ
DELANEY, CL
BIRD, JE
WALDRON, TL
MORELAND, S
机构：
[1] The Bristol-Myers-Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 12期
关键词：
D O I：
10.1016/S0960-894X(01)80738-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Quinoxaline heterocycle containing angiotensin II receptor antagonist analogs were prepared. All five analogs reported here display potent antagonistic activities and most interestingly, quinoxaline bis-N-oxide 10 exhibits very potent activities both in binding and functional assays.
引用
收藏
页码：2667 / 2670
页数：4
相关论文
共 50 条
  • [31] DIHYDROPYRIMIDINE ANGIOTENSIN-II RECEPTOR ANTAGONISTS
    ATWAL, KS
    AHMED, SZ
    BIRD, JE
    DELANEY, CL
    DICKINSON, KEJ
    FERRARA, FN
    HEDBERG, A
    MILLER, AV
    MORELAND, S
    OREILLY, BC
    SCHAEFFER, TR
    WALDRON, TL
    WELLER, HN
    JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (25) : 4751 - 4763
  • [32] NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS
    TIMMERMANS, PBMWM
    WONG, PC
    CHIU, AT
    HERBLIN, WF
    TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (02) : 55 - 62
  • [33] SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 1-AMINOPHTHALAZINIUM SALTS AS GABA(A) RECEPTOR ANTAGONISTS
    COLOTTA, V
    CECCHI, L
    CATARZI, D
    FILACCHIONI, G
    GALLI, A
    MORI, F
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 1994, 29 (02) : 95 - 105
  • [34] LEUKOTRIENE RECEPTOR ANTAGONISTS .1. SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF ALKOXYACETOPHENONE DERIVATIVES
    MARSHALL, WS
    GOODSON, T
    CULLINAN, GJ
    SWANSONBEAN, D
    HAISCH, KD
    RINKEMA, LE
    FLEISCH, JH
    JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (04) : 682 - 689
  • [35] DESIGN, SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF A SERIES OF POTENT NONPEPTIDE ENDOTHELIN RECEPTOR ANTAGONISTS
    LAGO, MA
    COUSINS, RD
    GAO, AM
    LEBER, JD
    PEISHOFF, CE
    OHLSTEIN, EH
    ELLIOTT, JD
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1994, 208 : 143 - MEDI
  • [36] STRUCTURE-ACTIVITY-RELATIONSHIPS OF CALMODULIN ANTAGONISTS
    PROZIALECK, WC
    ANNUAL REPORTS IN MEDICINAL CHEMISTRY, 1983, 18 : 203 - 212
  • [37] THE SYNTHESIS AND BIOLOGICAL-ACTIVITY OF TETRAHYDROQUINOLINE ANGIOTENSIN-II ANTAGONISTS CONTAINING A SUBSTITUTED BIPHENYLTETRAZOLE GROUP
    THOMAS, AP
    ROBERTS, DA
    THOMASON, DA
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (21) : 2615 - 2620
  • [38] Quantitative structure-activity relationships of benzoyliminothiadiazoline derivatives as angiotensin II receptor antagonists
    Hirata, T
    Goto, S
    Tamura, K
    Okuhira, M
    Nagao, Y
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1997, 7 (04) : 385 - 388
  • [39] IMIDAZOLINONES AS NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS
    QUAN, ML
    DELUCCA, I
    BOSWELL, GA
    CHIU, AT
    WONG, PC
    WEXLER, RR
    TIMMERMANS, PBMWM
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (12) : 1527 - 1530
  • [40] DIACIDIC NONPEPTIDE ANGIOTENSIN-II RECEPTOR ANTAGONISTS
    MANTLO, NB
    ONDEYKA, D
    CHANG, RSL
    LOTTI, VJ
    KIVLIGHN, SD
    SIEGL, PKS
    PATCHETT, AA
    GREENLEE, WJ
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1991, 202 : 103 - MEDI
12345