EFFECT OF CALCIUM-CHANNEL BLOCKERS ON ALCOHOL-CONSUMPTION IN ALCOHOL-DRINKING MONKEYS

被引：43
|
作者：
REZVANI, AH [1 ]
GRADY, DR [1 ]
JANOWSKY, DS [1 ]
机构：
[1] UNIV N CAROLINA, SCH MED, DEPT PSYCHIAT, CHAPEL HILL, NC 27599 USA
来源：
ALCOHOL AND ALCOHOLISM | 1991年 / 26卷 / 02期
关键词：
D O I：
10.1093/oxfordjournals.alcalc.a045097
中图分类号：
R194 [卫生标准、卫生检查、医药管理];
学科分类号：
摘要：
Experiments were performed to determine the effect of the calcium-channel blockers verapamil and diltiazem on ethanol preference in monkeys. Two days of administration of 10 mg/kg verapamil but not diltiazem or saline significantly decreased ethanol intake in all monkeys tested. Chronic treatment with verapamil, but not saline, dose-dependently attenuated alcohol intake, without significantly influencing water intake. These findings suggest that verapamil exerts an inhibitory action on ethanol preference in chronically alcohol-drinking monkeys, possibly by interfering with Ca2+-channels and/or by interacting with the activity of certain central neurotransmitters.
引用
收藏
页码：161 / 167
页数：7
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