EFFECT OF CALCIUM-CHANNEL BLOCKERS ON ALCOHOL-CONSUMPTION IN ALCOHOL-DRINKING MONKEYS

被引：43

作者：

REZVANI, AH ^{[1
]}

GRADY, DR ^{[1
]}

JANOWSKY, DS ^{[1
]}

机构：

[1] UNIV N CAROLINA, SCH MED, DEPT PSYCHIAT, CHAPEL HILL, NC 27599 USA

来源：

ALCOHOL AND ALCOHOLISM | 1991年 / 26卷 / 02期

关键词：

D O I：

10.1093/oxfordjournals.alcalc.a045097

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Experiments were performed to determine the effect of the calcium-channel blockers verapamil and diltiazem on ethanol preference in monkeys. Two days of administration of 10 mg/kg verapamil but not diltiazem or saline significantly decreased ethanol intake in all monkeys tested. Chronic treatment with verapamil, but not saline, dose-dependently attenuated alcohol intake, without significantly influencing water intake. These findings suggest that verapamil exerts an inhibitory action on ethanol preference in chronically alcohol-drinking monkeys, possibly by interfering with Ca2+-channels and/or by interacting with the activity of certain central neurotransmitters.

引用

页码：161 / 167

页数：7

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