TRANSLOCATION (11-15)(Q23-Q14) IN 3 PATIENTS WITH ACUTE NONLYMPHOBLASTIC LEUKEMIA (ANLL) - CLINICAL, CYTOGENETIC AND MOLECULAR STUDIES

被引：0

作者：

HERNANDEZ, JM

MECUCCI, C

BEVERLOO, HB

SELLERI, L

WLODARSKA, I

STUL, M

MICHAUX, L

VERHOEF, G

VANORSHOVEN, A

CASSIMAN, JJ

EVANS, GA

HAGEMEIJER, A

VANDENBERGHE, H

机构：

[1] UNIV LOUVAIN,CTR HUMAN GENET,B-3000 LOUVAIN,BELGIUM

[2] UNIV LOUVAIN,DEPT HEMATOL,B-3000 LOUVAIN,BELGIUM

[3] UNIV PERUGIA,HAEMATOL & BONE MARROW TRANSPLANTAT UNIT,PERUGIA,ITALY

[4] ERASMUS UNIV ROTTERDAM,DEPT CELL BIOL & GENET,ROTTERDAM,NETHERLANDS

[5] SALK INST BIOL STUDIES,LA JOLLA,CA

来源：

LEUKEMIA | 1995年 / 9卷 / 07期

关键词：

T(11-15); ACUTE NONLYMPHOBLASTIC LEUKEMIA; HTRX1/MLL GENE;

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report on three patients with acute non-lymphoblastic leukemia (ANLL) displaying the same chromosomal translocation t(11;15)(q23;q14). The clinical course of the disease was aggressive, and survival was short. The FAB subtype was M-2 in two cases, and M-1 in the remaining patient. Immunologically two cases showed aberrant expression of a lymphoid antigen (CD19 and TdT, respectively). HTRX1/MLL gene was rearranged in one patient studied at the time of diagnosis. These results plus data scattered in the literature show that the t(11;15)(q23;q14) can be added to the list of recurrent rearrangements in ANLL involving 11q23.

引用

页码：1162 / 1166

页数：5

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