TRANSLOCATION (11-15)(Q23-Q14) IN 3 PATIENTS WITH ACUTE NONLYMPHOBLASTIC LEUKEMIA (ANLL) - CLINICAL, CYTOGENETIC AND MOLECULAR STUDIES

被引：0
|
作者：
HERNANDEZ, JM
MECUCCI, C
BEVERLOO, HB
SELLERI, L
WLODARSKA, I
STUL, M
MICHAUX, L
VERHOEF, G
VANORSHOVEN, A
CASSIMAN, JJ
EVANS, GA
HAGEMEIJER, A
VANDENBERGHE, H
机构：
[1] UNIV LOUVAIN,CTR HUMAN GENET,B-3000 LOUVAIN,BELGIUM
[2] UNIV LOUVAIN,DEPT HEMATOL,B-3000 LOUVAIN,BELGIUM
[3] UNIV PERUGIA,HAEMATOL & BONE MARROW TRANSPLANTAT UNIT,PERUGIA,ITALY
[4] ERASMUS UNIV ROTTERDAM,DEPT CELL BIOL & GENET,ROTTERDAM,NETHERLANDS
[5] SALK INST BIOL STUDIES,LA JOLLA,CA
来源：
LEUKEMIA | 1995年 / 9卷 / 07期
关键词：
T(11-15); ACUTE NONLYMPHOBLASTIC LEUKEMIA; HTRX1/MLL GENE;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report on three patients with acute non-lymphoblastic leukemia (ANLL) displaying the same chromosomal translocation t(11;15)(q23;q14). The clinical course of the disease was aggressive, and survival was short. The FAB subtype was M-2 in two cases, and M-1 in the remaining patient. Immunologically two cases showed aberrant expression of a lymphoid antigen (CD19 and TdT, respectively). HTRX1/MLL gene was rearranged in one patient studied at the time of diagnosis. These results plus data scattered in the literature show that the t(11;15)(q23;q14) can be added to the list of recurrent rearrangements in ANLL involving 11q23.
引用
收藏
页码：1162 / 1166
页数：5
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