A NEW SYNTHESIS OF 5-BROMOAPLYSINOPSIN, 6-BROMOAPLYSINOPSIN AND 3'-DEMETHYLAPLYSINOPSIN AND THEIR BIOLOGICAL-ACTIVITIES

被引：0
|
作者：
GULATI, D [1 ]
CHAUHAN, PMS [1 ]
PRATAP, R [1 ]
BHAKUNI, DS [1 ]
机构：
[1] CENT DRUG RES INST,DIV MED CHEM,LUCKNOW 226001,UTTAR PRADESH,INDIA
来源：
INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 1994年 / 33卷 / 01期
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D O I：
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中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new synthesis of 5-bromoaplysinopsin (11), 6-bromoaplysinopsin (15) and 3-demethylaplysinopsin (24) has been developed. A number of their analogues have been synthesized and evaluated for biological activities. Of the compounds tested, compounds 5,7-9 are active against the fungus Sporotrichum schenckii, 6, 8, and 11 active against Trichophyton mentagrophytes and 8 against Cryptococcus neoformans. Compound 8 also exhibits moderate antiviral activity. Compounds 2, 8 and 9 show significant in vitroactivity against Leishmania donovanti a dose of 100 mug/ml.
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页码：10 / 16
页数：7
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