SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF [E]-5-(2-ACYLVINYL)URACILS

被引：28
|
作者：
KUNDU, NG [1 ]
DASGUPTA, SK [1 ]
CHAUDHURI, LN [1 ]
MAHANTY, JS [1 ]
SPEARS, CP [1 ]
SHAHINIAN, AH [1 ]
机构：
[1] UNIV SO CALIF,CTR COMPREHENS CANC,CANC RES LAB,LOS ANGELES,CA 90033
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 06期
关键词：
E]-5-(2-ACYLVINYL)URACILS; ANTICANCER AGENTS; THYMIDYLATE SYNTHASE INHIBITORS;
D O I：
10.1016/0223-5234(93)90015-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of a number of 5-substituted uracils, eg [E]-5-(2-acylvinyl)uracils 8a-8g is described. These compounds were found to have cytotoxic activities against CCRF-CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mouse leukemia cells. These compounds were also found to inhibit thymidylate synthase.
引用
收藏
页码：473 / 479
页数：7
相关论文
共 50 条
  • [1] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF 5-(2-ACYLVINYL)URACILS
    KUNDU, NG
    DASGUPTA, SK
    CHAUDHURI, LN
    MAHANTY, JS
    SPEARS, CP
    SHAHINIAN, AH
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1992, 204 : 127 - MEDI
  • [2] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF 5-(ACYLETHYNYL)URACILS, 5-(2-ACYLVINYL)URACILS AND THEIR CORRESPONDING 2'-DEOXYRIBONUCLEOSIDES
    KUNDU, NG
    MAHANTY, JS
    DASGUPTA, SK
    SPEARS, CP
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 206 : 108 - MEDI
  • [3] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF 6-(2-ACYLVINYL)URACILS
    DAS, P
    KUNDU, NG
    SPEARS, CP
    SU, S
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1995, 209 : 37 - MEDI
  • [4] SYNTHESIS OF NOVEL 5-(2-ACYLVINYL)URACILS
    KUNDU, NG
    CHAUDHURI, LN
    JOURNAL OF CHEMICAL RESEARCH-S, 1992, (02): : 64 - 65
  • [5] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF NOVEL 5-(2-ACYLETHYNYL)URACILS
    KUNDU, NG
    DAS, B
    SPEARS, CP
    MAJUMDAR, A
    KANG, SI
    JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (07) : 1975 - 1979
  • [6] PALLADIUM-CATALYZED SYNTHESIS OF (E)-5-(2-ACYLVINYL)-2'-DEOXYURIDINES AND THEIR ANTIVIRAL AND CYTOTOXIC ACTIVITIES
    KUNDU, NG
    MAHANTY, JS
    SPEARS, CP
    ANDREI, G
    SNOECK, R
    BALZARINI, J
    DECLERCQ, E
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (15) : 1627 - 1632
  • [7] Uracil derivatives and analogues .24. Palladium-catalyzed synthesis of [E]-6-(2-acylvinyl)uracils and [E]-6-(2-acylvinyl)-1-[(2-hydroxyethoxy)methyl]uracils - their antiviral and cytotoxic activities
    Kundu, NG
    Das, P
    Balzarini, J
    DeClercq, E
    BIOORGANIC & MEDICINAL CHEMISTRY, 1997, 5 (11) : 2011 - 2018
  • [8] STUDIES ON URACIL DERIVATIVES AND ANALOGS .14. A HIGHLY CONVENIENT PROCEDURE FOR THE SYNTHESIS OF 5-(2-ACYLVINYL)URACILS, A GROUP OF NOVEL 5-SUBSTITUTED URACILS
    KUNDU, NG
    CHAUDHURI, LN
    DASGUPTA, SK
    JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1990, (06): : 1822 - 1824
  • [9] PALLADIUM-CATALYZED SYNTHESIS OF 6-(2-ACYLVINYL)URACILS, A GROUP OF NOVEL 6-SUBSTITUTED URACILS OF BIOLOGICAL SIGNIFICANCE
    KUNDU, NG
    DAS, P
    JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (01) : 99 - 100
  • [10] PALLADIUM-CATALYZED SYNTHESIS OF 6-(2-ACYLVINYL)URACILS, A GROUP OF NOVEL 6-SUBSTITUTED URACILS OF BIOLOGICAL SIGNIFICANCE (JANUARY, PG 99, 1995)
    KUNDU, NG
    DAS, P
    JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1995, (11) : 1195 - 1195
12345