SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF [E]-5-(2-ACYLVINYL)URACILS

被引：28
|
作者：
KUNDU, NG [1 ]
DASGUPTA, SK [1 ]
CHAUDHURI, LN [1 ]
MAHANTY, JS [1 ]
SPEARS, CP [1 ]
SHAHINIAN, AH [1 ]
机构：
[1] UNIV SO CALIF,CTR COMPREHENS CANC,CANC RES LAB,LOS ANGELES,CA 90033
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1993年 / 28卷 / 06期
关键词：
E]-5-(2-ACYLVINYL)URACILS; ANTICANCER AGENTS; THYMIDYLATE SYNTHASE INHIBITORS;
D O I：
10.1016/0223-5234(93)90015-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of a number of 5-substituted uracils, eg [E]-5-(2-acylvinyl)uracils 8a-8g is described. These compounds were found to have cytotoxic activities against CCRF-CEM human lymphoblastoid cells, HT-29 colon carcinoma cells and L1210/0 mouse leukemia cells. These compounds were also found to inhibit thymidylate synthase.
引用
收藏
页码：473 / 479
页数：7
相关论文
共 50 条
  • [21] 8-METHYLADENOSINE-SUBSTITUTED ANALOGS OF 2-5A - SYNTHESIS AND THEIR BIOLOGICAL-ACTIVITIES
    KITADE, Y
    NAKATA, Y
    HIROTA, K
    MAKI, Y
    PABUCCUOGLU, A
    TORRENCE, PF
    NUCLEIC ACIDS RESEARCH, 1991, 19 (15) : 4103 - 4108
  • [22] SYNTHESIS OF ADRENAL PEPTIDE-E AND SOME OF ITS BIOLOGICAL-ACTIVITIES
    HEIMER, EP
    LAMBROS, TJ
    FELIX, AM
    FLEMINGER, G
    LI, CH
    WESTPHAL, M
    MEIENHOFER, J
    ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1983, 225 (02) : 518 - 524
  • [23] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF MITOMYCIN DERIVATIVES
    NAKANO, KI
    HETEROCYCLES, 1979, 13 : 373 - 387
  • [24] NUCLEOSIDE IMIDODIPHOSPHATES SYNTHESIS AND BIOLOGICAL-ACTIVITIES
    TOMASZ, J
    VAGHEFI, MM
    RATSEP, PC
    WILLIS, RC
    ROBINS, RK
    NUCLEIC ACIDS RESEARCH, 1988, 16 (17) : 8645 - 8664
  • [25] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF PHOSPHONYLALKYLPURINE DERIVATIVES
    KIM, CU
    LUH, BY
    MISCO, PF
    BRONSON, JJ
    HITCHCOCK, MJM
    GHAZZOULI, I
    MARTIN, JC
    NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, 1989, 8 (5-6): : 927 - 931
  • [26] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF SYNEPHRINE DERIVATIVES
    EYA, BK
    FUKUTO, TR
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1985, 189 (APR-): : 124 - PEST
  • [27] STUDIES ON THE SYNTHESIS OF BIHETEROCYCLES AND THEIR BIOLOGICAL-ACTIVITIES
    HIREMATH, SP
    SWAMY, HKS
    MRUTHYUNJAYASWAMY, BHM
    PATIL, SM
    SWAMY, KMK
    SHANTAKUMAR, SM
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1995, 72 (06) : 391 - 393
  • [28] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF GRISEOFULVIN ANALOGS
    KO, BS
    ORITANI, T
    YAMASHITA, K
    AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1990, 54 (09): : 2199 - 2204
  • [29] STUDIES ON SYNTHESIS OF MONOSACCHARIDES AND THEIR BIOLOGICAL-ACTIVITIES
    IKEKAWA, T
    OHKAWA, M
    MATSUDA, H
    KATORI, T
    JOURNAL OF PHARMACEUTICAL SCIENCES, 1987, 76 (11) : S156 - S156
  • [30] SYNTHESIS AND BIOLOGICAL-ACTIVITIES OF PHENYLCARBAMATES AND PHENYLTHIOCARBAMATES
    NAGAO, Y
    ABE, Y
    MISONO, T
    ICHIZEN, N
    SHIMA, Y
    IESAKA, H
    FURUSHIMA, M
    NIPPON KAGAKU KAISHI, 1993, (06) : 719 - 727
12345