THIENO-COMPOUNDS .10. SYNTHESIS OF 3,5,6-TRISUBSTITUTED 2-ALKYLTHIO-3,4-DIHYDRO-4-OXOTHIENO[2,3-D]PYRIMIDINES

被引：0

作者：

BOHM, R

MULLER, R

PECH, R

机构：

来源：

PHARMAZIE | 1990年 / 45卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of a number of new 2-alkylthio-3,4-dihydro-4-oxothieno[2,3-d]pyrimidines is described. Starting from 2-aminothiophene derivatives and thiophosgen the corresponding isothiocyanates were prepared, which react with aminoacids or their esters to give N,N'-disubstituted thioureas. These compounds were cyclized in a basic solution to form 1,2,3,4-tetrahydro-4-oxo-2-thioxothieno[2,3-d]pyrimidines having a carboxylic group in position 3. By different alkylating agents S-alkylated and esterified products can be obtained.

引用

页码：827 / 829

页数：3

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