THIENO-COMPOUNDS .10. SYNTHESIS OF 3,5,6-TRISUBSTITUTED 2-ALKYLTHIO-3,4-DIHYDRO-4-OXOTHIENO[2,3-D]PYRIMIDINES

被引：0

作者：

BOHM, R

MULLER, R

PECH, R

机构：

来源：

PHARMAZIE | 1990年 / 45卷 / 11期

关键词：

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of a number of new 2-alkylthio-3,4-dihydro-4-oxothieno[2,3-d]pyrimidines is described. Starting from 2-aminothiophene derivatives and thiophosgen the corresponding isothiocyanates were prepared, which react with aminoacids or their esters to give N,N'-disubstituted thioureas. These compounds were cyclized in a basic solution to form 1,2,3,4-tetrahydro-4-oxo-2-thioxothieno[2,3-d]pyrimidines having a carboxylic group in position 3. By different alkylating agents S-alkylated and esterified products can be obtained.

引用

页码：827 / 829

页数：3

共 50 条

[21] SYNTHESIS OF 2-METHYLENE-2,3-DIHYDRO AND 2-METHYL-5H-THIAZOLO[3,2-A]THIENO[2,3-D]PYRIMIDINES
SAUTER, F
DEINHAMM.W
DANKSAGM.K
MONATSHEFTE FUR CHEMIE, 1974, 105 (04): : 863 - 868
[22] Synthesis of new thieno[2,3-d]pyrimidines, thieno[3,2-e]pyridines, and thieno[2,3-d][1,3]oxazines
Kanawade, Shrikant B.
Patil, Shivaraj P.
Nikam, Prashant S.
Gangurde, Sachin A.
Jachak, Madhukar N.
Toche, Raghunath B.
JOURNAL OF HETEROCYCLIC CHEMISTRY, 2012, 49 (02) : 363 - 369
[23] STUDIES ON URACILS .10. A FACILE ONE-POT SYNTHESIS OF PYRIDO[2,3-D]PYRIMIDINES AND PYRAZOLO[3,4-D]PYRIMIDINES
BHUYAN, P
BORUAH, RC
SANDHU, JS
JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (02): : 568 - 571
[24] Synthesis of new furo[2,3-d]pyrimidines and Pyrimido[4′,5′:4,5]furo[2,3-d]pyrimidines
Moneam, MIA
Geies, AA
El-Naggar, GM
Mousa, SM
JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 2004, 51 (06) : 1357 - 1366
[25] SYNTHESIS OF THIENO[2,3-D]PYRIMIDINES FROM 4,6-DICHLOROPYRIMIDINE-5-CARBALDEHYDES
CLARK, J
SHAHHET, MS
KORAKAS, D
VARVOUNIS, G
JOURNAL OF HETEROCYCLIC CHEMISTRY, 1993, 30 (04) : 1065 - 1072
[26] SYNTHESIS OF 2-SUBSTITUTED AND 4-SUBSTITUTED THIENO[2,3-D]PYRIMIDINES
BOURGUIGNON, J
MOREAU, M
QUEGUINER, G
PASTOUR, P
BULLETIN DE LA SOCIETE CHIMIQUE DE FRANCE PARTIE II-CHIMIE MOLECULAIRE ORGANIQUE ET BIOLOGIQUE, 1975, (11-1): : 2483 - 2487
[27] Isolation of intermediates in the synthesis of new 3,4-dihydro-2H-chromeno[2,3-d]pyrimidines
Fattahi, Mehri
Davoodnia, Abolghasem
Pordel, Mehdi
Beyramabadi, S. Ali
Tavakoli-Hoseini, Niloofar
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2018, 73 (08): : 557 - 563
[28] SYNTHESIS OF SOME 5-(SUBSTITUTED AMINO)THIENO[2,3-D]PYRIMIDINES
TUMKYAVICHIUS, S
KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 1995, (07): : 986 - 990
[29] Syntheses of some new azolopyrido[4′,3′:4,5]thieno[2,3-d]pyrimidines
Ahmed, EK
HETEROATOM CHEMISTRY, 2002, 13 (03) : 280 - 286
[30] Synthesis and reactions of some new heterocyclic compounds related to pyrrolylthieno[2,3-d]pyrimidines and thieno[2,3-d][4,5-d]dipyrimidines
Moneam, MIA
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2005, 180 (02) : 633 - 646

← 1 2 3 4 5 →