EFFECTS OF ANTAGONISTS ON N-METHYL-D-ASPARTATE RESPONSE IN ACUTELY ISOLATED NUCLEUS TRACTUS SOLITARII NEURONS OF THE RAT

被引：28
|
作者：
NAKAGAWA, T [1 ]
SHIRASAKI, T [1 ]
TATEISHI, N [1 ]
MURASE, K [1 ]
AKAIKE, N [1 ]
机构：
[1] TOHOKU UNIV, SCH MED, DEPT NEUROPHYSIOL, SENDAI, MIYAGI 980, JAPAN
来源：
NEUROSCIENCE LETTERS | 1990年 / 113卷 / 02期
关键词：
Antagonist; Dissociated neuron; Internal perfusion; N-Methyl-d-aspartate; Nucleus tractus solitarius; Rat; Voltage-clamp;
D O I：
10.1016/0304-3940(90)90298-N
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of antagonists on N-methyl-d-aspartate (NMDA)-induced response was investigated in isolated nucleus tractus solitarii (NTS) neurons freshly isolated from the rat using a conventional patch-clamp technique. The NMDA-induced inward current consisted of an initial peak followed by a steadystate component. The competitive antagonists of NMDA receptor, d-2-amino-5-phosphonovalerate (APV), d-2-amino-4-phosphonoheptanoate (APH) and 3-3(2-carboxypiperazine-4-yl)propyl-1-phosphate (CPP), selectively suppressed the initial peak of NMDA-induced current more than the steady-state component at low concentrations. The non-competitive antagonists, MK-801, ketamine, Zn2+ and Mg2+, equally blocked both peak and steady-state components. © 1990.
引用
收藏
页码：169 / 174
页数：6
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