EFFECTS OF ANTAGONISTS ON N-METHYL-D-ASPARTATE RESPONSE IN ACUTELY ISOLATED NUCLEUS TRACTUS SOLITARII NEURONS OF THE RAT

被引：28

作者：

NAKAGAWA, T ^{[1
]}

SHIRASAKI, T ^{[1
]}

TATEISHI, N ^{[1
]}

MURASE, K ^{[1
]}

AKAIKE, N ^{[1
]}

机构：

[1] TOHOKU UNIV, SCH MED, DEPT NEUROPHYSIOL, SENDAI, MIYAGI 980, JAPAN

来源：

NEUROSCIENCE LETTERS | 1990年 / 113卷 / 02期

关键词：

Antagonist; Dissociated neuron; Internal perfusion; N-Methyl-d-aspartate; Nucleus tractus solitarius; Rat; Voltage-clamp;

D O I：

10.1016/0304-3940(90)90298-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of antagonists on N-methyl-d-aspartate (NMDA)-induced response was investigated in isolated nucleus tractus solitarii (NTS) neurons freshly isolated from the rat using a conventional patch-clamp technique. The NMDA-induced inward current consisted of an initial peak followed by a steadystate component. The competitive antagonists of NMDA receptor, d-2-amino-5-phosphonovalerate (APV), d-2-amino-4-phosphonoheptanoate (APH) and 3-3(2-carboxypiperazine-4-yl)propyl-1-phosphate (CPP), selectively suppressed the initial peak of NMDA-induced current more than the steady-state component at low concentrations. The non-competitive antagonists, MK-801, ketamine, Zn2+ and Mg2+, equally blocked both peak and steady-state components. © 1990.

引用

页码：169 / 174

页数：6

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