ENANTIOSPECIFIC ANALYSIS OF KETOPROFEN IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：26
|
作者：
HAYBALL, PJ
NATION, RL
BOCHNER, F
LELEU, RK
机构：
[1] UNIV ADELAIDE,DEPT CLIN & EXPTL PHARMACOL,ADELAIDE,SA 5000,AUSTRALIA
[2] UNIV S AUSTRALIA,SCH PHARM,ADELAIDE,SA 5000,AUSTRALIA
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 570卷 / 02期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0378-4347(91)80552-N
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A high-performance liquid chromatographic (HPLC) assay for the determination of the R- and S-enantiomers of ketoprofen is described. Facile ketoprofen extraction from plasma and derivatization to the diastereomeric S-1-phenylethylamides was followed by normal-phase HPLC. The ketoprofen diastereomeric amides eluted within 8 min. The limit of quantification of the assay was 0.15 mg/l of each enantiomer (signal-to-noise ratio = 5).
引用
收藏
页码：446 / 452
页数：7
相关论文
共 50 条
  • [41] QUANTITATION OF BUSULFAN IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    MACKICHAN, JJ
    BECHTEL, TP
    JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 1990, 532 (02): : 424 - 428
  • [42] ASSAY OF GEMFIBROZIL IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    FORLAND, SC
    CHAPLIN, L
    CUTLER, RE
    CLINICAL CHEMISTRY, 1987, 33 (10) : 1938 - 1938
  • [43] DETERMINATION OF TOLAZOLINE IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    ROVEI, V
    REMONES, G
    THENOT, JP
    MORSELLI, PL
    JOURNAL OF CHROMATOGRAPHY, 1982, 231 (01): : 210 - 215
  • [44] DETERMINATION OF PYRROLIDINONE IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    DELL, D
    WENDT, G
    BUCHELI, F
    TRAUTMANN, KH
    JOURNAL OF CHROMATOGRAPHY, 1985, 344 (NOV): : 125 - 136
  • [45] DETERMINATION OF ATRACURIUM IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    STILLER, RL
    BRANDOM, BW
    COOK, DR
    ANESTHESIA AND ANALGESIA, 1985, 64 (01): : 58 - 62
  • [46] DETERMINATION OF AMOXAPINE IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    SHIPE, JR
    SAVORY, J
    WILLS, MR
    CLINICAL CHEMISTRY, 1982, 28 (07) : 1643 - 1643
  • [47] DETERMINATION OF CINNARIZINE IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    HUNDT, HKL
    BROWN, LW
    CLARK, EC
    JOURNAL OF CHROMATOGRAPHY, 1980, 183 (03): : 378 - 382
  • [48] DETERMINATION OF ISOXEPAC IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    SLACK, JA
    JOURNAL OF CHROMATOGRAPHY, 1980, 221 (02): : 431 - 434
  • [49] HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY OF PROPANIDID IN RAT PLASMA
    NOUSIAINEN, U
    RAATIKAINEN, O
    JOURNAL OF CHROMATOGRAPHY, 1984, 308 (JUN): : 376 - 381
  • [50] MEASUREMENT OF NICOTINE IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY
    HEFNER, JE
    WILLIAMS, AG
    ROBINSON, EJ
    DOWNEY, HF
    JOURNAL OF LIQUID CHROMATOGRAPHY, 1988, 11 (11): : 2375 - 2389
12345