ENANTIOSPECIFIC ANALYSIS OF KETOPROFEN IN PLASMA BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY

被引：26
|
作者：
HAYBALL, PJ
NATION, RL
BOCHNER, F
LELEU, RK
机构：
[1] UNIV ADELAIDE,DEPT CLIN & EXPTL PHARMACOL,ADELAIDE,SA 5000,AUSTRALIA
[2] UNIV S AUSTRALIA,SCH PHARM,ADELAIDE,SA 5000,AUSTRALIA
来源：
JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS | 1991年 / 570卷 / 02期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0378-4347(91)80552-N
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A high-performance liquid chromatographic (HPLC) assay for the determination of the R- and S-enantiomers of ketoprofen is described. Facile ketoprofen extraction from plasma and derivatization to the diastereomeric S-1-phenylethylamides was followed by normal-phase HPLC. The ketoprofen diastereomeric amides eluted within 8 min. The limit of quantification of the assay was 0.15 mg/l of each enantiomer (signal-to-noise ratio = 5).
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页码：446 / 452
页数：7
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