BENZO[A]PYRENE METABOLISM IN NEONATAL RAT-LIVER NUCLEI

被引：9
|
作者：
BRESNICK, E [1 ]
CHUANG, AHL [1 ]
BORNSTEIN, WA [1 ]
机构：
[1] UNIV VERMONT, COLL MED, DEPT BIOCHEM, BURLINGTON, VT 05401 USA
来源：
CHEMICO-BIOLOGICAL INTERACTIONS | 1979年 / 24卷 / 01期
关键词：
D O I：
10.1016/0009-2797(79)90107-8
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ability of neonatal rat liver to form benzo[a]pyrene oxidative metabolites is investigated along with relative mixed function oxidase effects. Exposed liver tissues form benzo[a]pyrene proximate carcinogens even in the presence of lower microsomal activity especially in the presence of an inducer such as methylcholanthrene. Quantitative differences between adult and neonatal DNA enzyme systems are suggested for alkylated DNA repair.
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页码：111 / 115
页数：5
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