BENZO[A]PYRENE METABOLISM IN NEONATAL RAT-LIVER NUCLEI

被引：9

作者：

BRESNICK, E ^{[1
]}

CHUANG, AHL ^{[1
]}

BORNSTEIN, WA ^{[1
]}

机构：

[1] UNIV VERMONT, COLL MED, DEPT BIOCHEM, BURLINGTON, VT 05401 USA

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 1979年 / 24卷 / 01期

关键词：

D O I：

10.1016/0009-2797(79)90107-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of neonatal rat liver to form benzo[a]pyrene oxidative metabolites is investigated along with relative mixed function oxidase effects. Exposed liver tissues form benzo[a]pyrene proximate carcinogens even in the presence of lower microsomal activity especially in the presence of an inducer such as methylcholanthrene. Quantitative differences between adult and neonatal DNA enzyme systems are suggested for alkylated DNA repair.

引用

页码：111 / 115

页数：5

共 50 条

[21] EFFECT OF NORHARMAN ON METABOLISM OF BENZO[A]PYRENE BY RAT-LIVER MICROSOMES INVITRO IN RELATION TO ITS ENHANCEMENT OF MUTAGENICITY OF BENZO[A]PYRENE
FUJINO, T
FUJIKI, H
NAGAO, M
YAHAGI, T
SEINO, Y
SUGIMURA, T
MUTATION RESEARCH, 1978, 58 (2-3): : 151 - 158
[22] FORMATION IN ISOLATED RAT-LIVER MICROSOMES AND NUCLEI OF BENZO(A)PYRENE METABOLITES THAT BIND TO DNA
JERNSTROM, B
VADI, H
ORRENIUS, S
CANCER RESEARCH, 1976, 36 (11) : 4107 - 4113
[23] METABOLISM OF RAT-LIVER NUCLEI
HUGGINS, AK
ROWLAND, GF
BIOCHEMICAL JOURNAL, 1962, 84 (03) : P67 - &
[24] BENZO(A)PYRENE DEOXYRIBONUCLEOSIDE PRODUCTS ISOLATED FROM DNA AFTER METABOLISM OF BENZO(A)PYRENE BY RAT-LIVER MICROSOMES IN PRESENCE OF DNA
KING, HWS
THOMPSON, MH
BROOKES, P
CANCER RESEARCH, 1975, 35 (05) : 1263 - 1269
[25] BINDING OF BENZO(A)PYRENE TO RAT-LIVER NUCLEAR MATRIX
MATSUURA, T
NOMI, S
SAJI, Y
UEYAMA, H
UEDA, K
CELL STRUCTURE AND FUNCTION, 1979, 4 (04) : 367 - 367
[26] THE BINDING OF BENZO(A)PYRENE TO SUBCELLULAR STRUCTURES OF RAT-LIVER
HOMMES, FA
ELLER, AG
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1980, 11 (04): : 379 - 386
[27] BINDING OF BENZO(A)PYRENE TO RAT-LIVER NUCLEAR MATRIX
UEYAMA, H
MATSUURA, T
NOMI, S
NAKAYASU, H
UEDA, K
LIFE SCIENCES, 1981, 29 (07) : 655 - 661
[28] THE EFFECT OF PREGNANCY, LACTATION AND INDUCTION ON THE INVITRO METABOLISM OF BENZO[A]PYRENE BY RAT-LIVER MICROSOMES
KEYSELL, GR
DAVIES, MW
MUTAGENESIS, 1986, 1 (01) : 77 - 77
[29] EFFECT OF GAMMA-HEXACHLOROCYCLOHEXANE AND CAPTANE INGESTION ON BENZO(A)PYRENE METABOLISM IN RAT-LIVER
DECLOITRE, F
MIKOL, Y
FEDERATION PROCEEDINGS, 1977, 36 (03) : 348 - 348
[30] EFFECT OF DIETARY ANTI-OXIDANT ON BENZO[A]PYRENE METABOLISM IN RAT-LIVER MICROSOMES
KAHL, R
KAHL, GF
TOXICOLOGY, 1983, 28 (03) : 229 - 233

← 1 2 3 4 5 →