SYNTHESIS OF IMIDAZO[1,2-B]PYRIDAZINES - FENBENDAZOLE, OXIFENBENDAZOLE ANALOGS AND RELATED DERIVATIVES

被引：6
|
作者：
MOURAD, AE [1 ]
WISE, DS [1 ]
TOWNSEND, LB [1 ]
机构：
[1] UNIV MICHIGAN,DEPT CHEM,ANN ARBOR,MI 48109
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1993年 / 30卷 / 05期
关键词：
D O I：
10.1002/jhet.5570300531
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of imidazo[1,2-b]pyridazines has been prepared and evaluated for macrofilaricidal activity against Brugia pahangi or Acanthocheilonema viteae infections in jirds. The imidazo[1,2-b]pyridazine analogs of fenbendazole and oxifenbendazole are reported. In addition, several 6-aminoimidazo[1,2-b]pyridazine derivatives have been prepared. None of these compounds possessed significant activity against human cytomegalovirus (HCMV) or filarial infections.
引用
收藏
页码：1365 / 1372
页数：8
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