SYNTHESIS OF IMIDAZO[1,2-B]PYRIDAZINES - FENBENDAZOLE, OXIFENBENDAZOLE ANALOGS AND RELATED DERIVATIVES

被引：6
|
作者：
MOURAD, AE [1 ]
WISE, DS [1 ]
TOWNSEND, LB [1 ]
机构：
[1] UNIV MICHIGAN,DEPT CHEM,ANN ARBOR,MI 48109
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1993年 / 30卷 / 05期
关键词：
D O I：
10.1002/jhet.5570300531
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of imidazo[1,2-b]pyridazines has been prepared and evaluated for macrofilaricidal activity against Brugia pahangi or Acanthocheilonema viteae infections in jirds. The imidazo[1,2-b]pyridazine analogs of fenbendazole and oxifenbendazole are reported. In addition, several 6-aminoimidazo[1,2-b]pyridazine derivatives have been prepared. None of these compounds possessed significant activity against human cytomegalovirus (HCMV) or filarial infections.
引用
收藏
页码：1365 / 1372
页数：8
相关论文
共 50 条
  • [31] A novel approach for the synthesis of highly fluorescent pyrrolo[1,2-b]pyridazines
    Dumitrascu, Florea
    Caira, Mino R.
    Draghici, Bogdan
    Caproiu, Miron Teodor
    Dumitrescu, Dan G.
    SYNLETT, 2008, (06) : 813 - 816
  • [32] Pyrrolo[1,2-b]pyridazines. A revisit
    Dumitrascu, Florea
    Dumitrescu, Dan George
    ARKIVOC, 2008, : 232 - 270
  • [33] IMIDAZO[1,2-B]-AS-TRIAZINE
    RYKOWSKI, A
    VANDERPLAS, HC
    STAM, CH
    ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE, 1977, 33 (JAN15): : 274 - 276
  • [34] IMIDAZO[1,2-B]PYRIDAZINES .15. SYNTHESIS AND ANXIOLYTIC ACTIVITY OF SOME 3-(BENZAMIDOMETHYL AND FLUOROBENZAMIDOMETHYL)-6-(FLUORO, CHLORO AND METHYLTHIO)-2-(4-TOLYL AND 3,4-METHYLENEDIOXYPHENYL)IMIDAZO[1,2-B]PYRIDAZINES
    BARLIN, GB
    DAVIES, LP
    GLENN, B
    HARRISON, PW
    IRELAND, SJ
    AUSTRALIAN JOURNAL OF CHEMISTRY, 1994, 47 (04) : 609 - 621
  • [35] SYNTHESIS OF PYRIDAZINE DERIVATIVES .17. SOME REACTIONS ON 2-PHENYLIMIDAZO(1,2-B)PYRIDAZINES
    STANOVNI.B
    TISLER, M
    CROATICA CHEMICA ACTA, 1968, 40 (01) : 1 - &
  • [36] IMIDAZO[1,2-B]PYRIDAZINES .8. SYNTHESES AND CENTRAL NERVOUS-SYSTEM ACTIVITIES OF SOME 6-BENZYLAMINO (AND METHOXYBENZYLAMINO)-3-METHOXY-2-PHENYL(SUBSTITUTED PHENYL OR PYRIDINYL)IMIDAZO[1,2-B]PYRIDAZINES
    BARLIN, GB
    DAVIES, LP
    NGU, MML
    AUSTRALIAN JOURNAL OF CHEMISTRY, 1989, 42 (10) : 1759 - 1768
  • [37] IMIDAZO[1,2-B]PYRIDAZINES .5. SYNTHESES AND CENTRAL NERVOUS ACTIVITIES OF SOME 3-ALKOXY-6-BENZYLTHIO(SUBSTITUTED BENZYLTHIO AND OTHER PHENYLALKYLTHIO)-2-PHENYL(AND SUBSTITUTED PHENYL)IMIDAZO[1,2-B]PYRIDAZINES
    BARLIN, GB
    DAVIES, LP
    IRELAND, SJ
    NGU, MML
    AUSTRALIAN JOURNAL OF CHEMISTRY, 1989, 42 (07) : 1133 - 1146
  • [38] IMIDAZO[1,2-B]PYRIDAZINES .16. SYNTHESIS AND CENTRAL-NERVOUS-SYSTEM ACTIVITIES OF SOME 6-(CHLORO, ALKYLTHIO, PHENYLTHIO, BENZYLTHIO OR PYRIDINYLMETHYLTHIO)-3-(UNSUBSTITUTED, BENZAMIDOMETHYL OR METHOXY)-2-(STYRYL OR BENZOYL)IMIDAZO[1,2-B]PYRIDAZINES
    BARLIN, GB
    DAVIES, LP
    HARRISON, PW
    JACOBSEN, NW
    WILLIS, AC
    AUSTRALIAN JOURNAL OF CHEMISTRY, 1994, 47 (11) : 1989 - 1999
  • [39] Ligands for the central benzodiazepine receptor: Structure-affinity relationship studies on imidazo[1,2-b]pyridazines
    Matyus, P
    Barlin, GB
    Harrison, PW
    Wong, MG
    Davies, LP
    AUSTRALIAN JOURNAL OF CHEMISTRY, 1996, 49 (04) : 435 - 442
  • [40] Structural analysis identifies imidazo[1,2-b]Pyridazines as PIM kinase inhibitors with In vitro antileukemic activity
    Pogacic, Vanda
    Bullock, Alex N.
    Fedorov, Oleg
    Filippakopoulos, Panagis
    Gasser, Christelle
    Biondi, Andrea
    Meyer-Monard, Sandrine
    Knapp, Stefan
    Schwaller, Juerg
    CANCER RESEARCH, 2007, 67 (14) : 6916 - 6924
12345