EFFECTS OF ALPRAZOLAM ON T-CELL IMMUNOSUPPRESSIVE RESPONSE TO SURGICAL STRESS IN MICE

被引：23
|
作者：
FREIREGARABAL, M [1 ]
BELMONTE, A [1 ]
ORALLO, F [1 ]
COUCEIRO, J [1 ]
NUNEZ, MJ [1 ]
机构：
[1] UNIV SANTIAGO DE COMPOSTELA, FAC MED, DEPT PHARMACOL, E-15705 SANTIAGO, SPAIN
来源：
CANCER LETTERS | 1991年 / 58卷 / 03期
关键词：
STRESS; IMMUNITY; LYMPHOCYTES-T; BLASTIC RESPONSE; ALPRAZOLAM; ANXIOLYTICS; ADRENOCORTICOTROPIC HORMONE;
D O I：
10.1016/0304-3835(91)90098-3
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Mice submitted to surgical stress induced by laparotomy and treated with chronic alprazolam (1 mg/kg) showed a reduction in stress-induced suppression of thymus and spleen cellularity, as well as in peripheral T lymphocyte population. The blastic response of spleen lymphoid cells was also assessed and found to partially supress the inhibitory effect of surgery.
引用
收藏
页码：183 / 187
页数：5
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