2-(AMINOMETHYL)PHENOLS, A NEW CLASS OF SALURETIC AGENTS .2. SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF THE 5-AZA ISOSTERE OF 2-(AMINOMETHYL)-4-(1,1-DIMETHYLETHYL)-6-IODOPHENOL

被引：7
|
作者：
STOKKER, GE [1 ]
SMITH, RL [1 ]
CRAGOE, EJ [1 ]
LUDDEN, CT [1 ]
RUSSO, HF [1 ]
SWEET, CS [1 ]
WATSON, LS [1 ]
机构：
[1] MERCK INST THERAPEUT RES,W POINT,PA 19486
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 1981年 / 24卷 / 01期
关键词：
D O I：
10.1021/jm00133a024
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
引用
收藏
页码：115 / 117
页数：3
相关论文
共 50 条
  • [31] Synthesis of new 2-(aminomethyl)-4-phenylpyrrolo[1,2-a]quinoxalines and their preliminary in-vivo central dopamine antagonist activity evaluation in mice
    Guillon, J
    Boulouard, M
    Lisowski, V
    Stiebing, S
    Lelong, V
    Dallemagne, P
    Rault, S
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2000, 52 (11) : 1369 - 1375
  • [32] 2-[3-(1,1-DIMETHYLETHYL)-5-METHOXYPHENYLOXAZOLO[4,5-B]PYRIDINE, A NEW TOPICAL ANTIINFLAMMATORY AND ANALGESIC COMPOUND LACKING SYSTEMIC ACTIVITY AND GASTRIC SIDE-EFFECTS
    BONNEY, RJ
    OLSON, BJ
    BACH, T
    BEVERIDGE, G
    GOLDENBERG, MM
    GITTERMAN, CO
    HUMES, JL
    LU, AYH
    HUCKER, H
    DOUGHERTY, H
    JENSEN, N
    ARZNEIMITTEL-FORSCHUNG/DRUG RESEARCH, 1985, 35-1 (04): : 715 - 720
  • [33] Promising approach to the synthesis of unknown 2-(2, 2′-diamino-4,5′-dipyrimidin-6-yl)phenols(naphthols) and 2-amino-6-(2-hydroxyphenyl)-4-(4-nitrophenyl)nicotinonitriles
    Zahorulko, Serhii P.
    Varenichenko, Svetlana A.
    Farat, Oleg K.
    Mazepa, Aleksander V.
    Markov, Victor I.
    MONATSHEFTE FUR CHEMIE, 2021, 152 (01): : 77 - 82
  • [34] Promising approach to the synthesis of unknown 2-(2, 2′-diamino-4,5′-dipyrimidin-6-yl)phenols(naphthols) and 2-amino-6-(2-hydroxyphenyl)-4-(4-nitrophenyl)nicotinonitriles
    Serhii P. Zahorulko
    Svetlana A. Varenichenko
    Oleg K. Farat
    Aleksander V. Mazepa
    Victor I. Markov
    Monatshefte für Chemie - Chemical Monthly, 2021, 152 : 77 - 82
  • [35] Novel 3-aminomethyl- and 4-aminopiperidine analogues of 1-[2-(diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: Synthesis and evaluation as dopamine transporter ligands
    Choi, SW
    Elmaleh, DR
    Hanson, RN
    Fischman, AJ
    JOURNAL OF MEDICINAL CHEMISTRY, 2000, 43 (02) : 205 - 213
  • [36] Synthesis of some new 2-(pyrazol-1-yl)-4-(pyrimidin-5-yl)thiazoles
    Ahluwalia, VK
    Sharma, P
    Goyal, B
    Aggarwal, R
    INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY, 1997, 36 (10): : 920 - 922
  • [37] Synthesis and Properties of New 2-[2-(N-alkyl)-pyridinium]-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide Iodide Radicals
    Antônio F. C. Alcântara
    Hélio F. Dos Santos
    Wagner B. De Almeida
    Maria G. F. Vaz
    Luíza M. M. Pinheiro
    Humberto O. Stumpf
    Structural Chemistry, 1999, 10 : 367 - 374
  • [38] Synthesis and properties of new 2-[2-(N-alkyl)-pyridinium]-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide iodide radicals
    Alcântara, AFC
    Dos Santos, HF
    De Almeida, WB
    Vaz, MGF
    Pinheiro, LMM
    Stumpf, HO
    STRUCTURAL CHEMISTRY, 1999, 10 (05) : 367 - 374
  • [39] Synthesis of some new 2-(4-nitrobenzothiazol-2′-ylamino)-4-(2-chloro-4-trifluoromethylanilino)-6-(substituted thioureido)-1,3,5-triazines as antifungal agents
    Sareen, Vineeta
    Khatri, Vineeta
    Garg, Urmila
    Jain, Prakash
    Sharma, Kanti
    PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, 2007, 182 (12) : 2943 - 2948
  • [40] Design and synthesis of 2-methyl-2-{4-[2-(5-methyl-2-aryloxazol-4-yl)ethoxy]phenoxy}propionic acids:: A new class of dual PPARα/γ agonists
    Brooks, DA
    Etgen, GJ
    Rito, CJ
    Shuker, AJ
    Dominianni, SJ
    Warshawsky, AM
    Ardecky, R
    Paterniti, JR
    Tyhonas, J
    Karanewsky, DS
    Kauffman, RF
    Broderick, CL
    Oldham, BA
    Montrose-Rafizadeh, C
    Winneroski, LL
    Faul, MM
    McCarthy, JR
    JOURNAL OF MEDICINAL CHEMISTRY, 2001, 44 (13) : 2061 - 2064
12345