Promising approach to the synthesis of unknown 2-(2, 2′-diamino-4,5′-dipyrimidin-6-yl)phenols(naphthols) and 2-amino-6-(2-hydroxyphenyl)-4-(4-nitrophenyl)nicotinonitriles

被引：0

作者：

Zahorulko, Serhii P. ^{[1
]}

Varenichenko, Svetlana A. ^{[1
]}

Farat, Oleg K. ^{[1
]}

Mazepa, Aleksander V. ^{[2
]}

Markov, Victor I. ^{[1
]}

机构：

[1] Ukrainian State Univ Chem Technol, 8 Gagarina Ave, Dnipro 49005, Ukraine

[2] Natl Acad Sci Ukraine, AV Bogatsky Physicochem Inst, 86 Lyustdorfskaya Rd, Odessa 65080, Ukraine

来源：

MONATSHEFTE FUR CHEMIE | 2021年 / 152卷 / 01期

关键词：

(4-Amino-2H-chromen-2-ylidene) malonaldehyde; 2-Aryl-4H-chromen-4-imines; Dipyrimidin-6-yl-phenols (naphthols); 2-Amino-6-(2-hydroxyphenyl)-4-(4-nitrophenyl) nicotinonitrile; 6-Exo-trig-cyclization; DINUCLEOPHILES; RECYCLIZATION; CLEAVAGE;

D O I：

10.1007/s00706-020-02719-x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Novel derivatives of 2-(2,2 '-diamino-4,5 '-bipyrimidin-6-yl)phenols(naphthols) were obtained in the reaction of (4-amino-2H-(benzo[g])chromen-2-ylidene)malondialdehyde with 1,3-dinucleophile proceeding as a cascade reaction initiated by the Michael reaction. It has been established that the recyclization of 2-aryl-4H-chromen-4-imines under the influence of malononitrile as C-nucleophile is completed by the formation of 2-amino-6-(2-hydroxyphenyl)-4-(4-nitrophenyl)nicotinonitrile by the 6-exo-trig-cyclization mechanism.

引用

页码：77 / 82

页数：6

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Serhii P. Zahorulko
Svetlana A. Varenichenko
Oleg K. Farat
Aleksander V. Mazepa
Victor I. Markov
Monatshefte für Chemie - Chemical Monthly, 2021, 152 : 77 - 82
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