Promising approach to the synthesis of unknown 2-(2, 2′-diamino-4,5′-dipyrimidin-6-yl)phenols(naphthols) and 2-amino-6-(2-hydroxyphenyl)-4-(4-nitrophenyl)nicotinonitriles

被引：0
|
作者：
Zahorulko, Serhii P. [1 ]
Varenichenko, Svetlana A. [1 ]
Farat, Oleg K. [1 ]
Mazepa, Aleksander V. [2 ]
Markov, Victor I. [1 ]
机构：
[1] Ukrainian State Univ Chem Technol, 8 Gagarina Ave, Dnipro 49005, Ukraine
[2] Natl Acad Sci Ukraine, AV Bogatsky Physicochem Inst, 86 Lyustdorfskaya Rd, Odessa 65080, Ukraine
来源：
MONATSHEFTE FUR CHEMIE | 2021年 / 152卷 / 01期
关键词：
(4-Amino-2H-chromen-2-ylidene) malonaldehyde; 2-Aryl-4H-chromen-4-imines; Dipyrimidin-6-yl-phenols (naphthols); 2-Amino-6-(2-hydroxyphenyl)-4-(4-nitrophenyl) nicotinonitrile; 6-Exo-trig-cyclization; DINUCLEOPHILES; RECYCLIZATION; CLEAVAGE;
D O I：
10.1007/s00706-020-02719-x
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Novel derivatives of 2-(2,2 '-diamino-4,5 '-bipyrimidin-6-yl)phenols(naphthols) were obtained in the reaction of (4-amino-2H-(benzo[g])chromen-2-ylidene)malondialdehyde with 1,3-dinucleophile proceeding as a cascade reaction initiated by the Michael reaction. It has been established that the recyclization of 2-aryl-4H-chromen-4-imines under the influence of malononitrile as C-nucleophile is completed by the formation of 2-amino-6-(2-hydroxyphenyl)-4-(4-nitrophenyl)nicotinonitrile by the 6-exo-trig-cyclization mechanism.
引用
收藏
页码：77 / 82
页数：6
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