One-Pot Synthesis of alpha-Substituted Acrylates

被引：3
|
作者：
Matziari, Magdalini [1 ]
Xie, Yixin [1 ]
机构：
[1] Xian Jiaotong Liverpool Univ, SIP, 111 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China
来源：
SYNOPEN | 2018年 / 2卷 / 02期
关键词：
acrylates; Horner-Wadsworth-Emmons reaction; amino-acid analogues; one-pot synthesis; beta-amino acids;
D O I：
10.1055/s-0037-1610357
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and efficient synthetic method towards alpha-substituted acrylic esters has been developed using the Horner-Wadsworth-Emmons (HWE) reaction with HCHO after alkylation of phosphonoacetates in a one-pot reaction. This method allows the smooth introduction of various side-chains, such as natural amino acids and other biologically relevant substituents. The use of mild conditions, inexpensive reagents, short reaction times and simple work-up and purification steps provides an effective and general alternative to cumbersome multistep and low-yielding procedures described to date.
引用
收藏
页码：161 / 167
页数：7
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