One-Pot Synthesis of alpha-Substituted Acrylates

被引：3

作者：

Matziari, Magdalini ^{[1
]}

Xie, Yixin ^{[1
]}

机构：

[1] Xian Jiaotong Liverpool Univ, SIP, 111 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China

来源：

SYNOPEN | 2018年 / 2卷 / 02期

关键词：

acrylates; Horner-Wadsworth-Emmons reaction; amino-acid analogues; one-pot synthesis; beta-amino acids;

D O I：

10.1055/s-0037-1610357

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and efficient synthetic method towards alpha-substituted acrylic esters has been developed using the Horner-Wadsworth-Emmons (HWE) reaction with HCHO after alkylation of phosphonoacetates in a one-pot reaction. This method allows the smooth introduction of various side-chains, such as natural amino acids and other biologically relevant substituents. The use of mild conditions, inexpensive reagents, short reaction times and simple work-up and purification steps provides an effective and general alternative to cumbersome multistep and low-yielding procedures described to date.

引用

页码：161 / 167

页数：7

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