SYNTHESIS OF [C-11] SARIN

被引：12
|
作者：
PRENANT, C
CROUZEL, C
机构：
[1] Service Hospitalier Frédéric Joliot, Département de Biologie Commissariat à l'Energie Atomique, Orsay
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1990年 / 28卷 / 06期
关键词：
D O I：
10.1002/jlcr.2580280604
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
[11C]‐acetone, prepared from 11CO2 and methyllithium, was reduced to [11C]‐isopropanol. The latter reacted with methylphosphonic acid difluoride in the presence of diisopropylamine, to yield [11C]‐sarin. 3.4 GBq (100 mCi) of [11C]‐sarin may be obtained from about 55.5 GBq (1.5 Ci) of 11CO2 in 40 minutes. The product purified by HPLC, is obtained with a specific radioactivity ranging from 22.2 to 33.3 GBq (600 to 900 mCi/μmol.). Copyright © 1990 John Wiley & Sons, Ltd.
引用
收藏
页码：645 / 651
页数：7
相关论文
共 50 条
  • [41] C-11 LABELING BY MALONIC ESTER SYNTHESIS
    OGAWA, K
    NIISAWA, K
    NOZAKI, T
    APPLIED RADIATION AND ISOTOPES, 1988, 39 (06) : 603 - 603
  • [42] A SEMIAUTOMATED SYNTHESIS SYSTEM FOR ROUTINE PREPARATION OF [C-11] YM-09151-2 AND [C-11] PYRILAMINE FROM [C-11] METHYL-IODIDE
    IWATA, R
    HATANO, K
    YANAI, K
    TAKAHASHI, T
    ISHIWATA, K
    IDO, T
    APPLIED RADIATION AND ISOTOPES, 1991, 42 (02) : 202 - 205
  • [43] Efficient synthesis of C-11 functionalized steroids
    Bazzini, Patrick
    Ibrahim-Ouali, Malika
    Pellissier, Helene
    Santelli, Maurice
    STEROIDS, 2006, 71 (06) : 459 - 468
  • [44] SYNTHESIS OF C-11 LABELED DOPA/ DOPA
    REIFFERS, S
    BEERLING, E
    VAALBURG, W
    TENHOEVE, W
    WOLDRING, MG
    WYNBERG, H
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1977, 13 (02): : 198 - 199
  • [45] A simple synthesis of [C-11]dihydrotetrabenazine (DTBZ)
    Jewett, DM
    Kilbourn, MR
    Lee, LC
    NUCLEAR MEDICINE AND BIOLOGY, 1997, 24 (02): : 197 - 199
  • [46] A SIMPLE SYNTHESIS OF [C-11] METHYL TRIFLATE
    JEWETT, DM
    APPLIED RADIATION AND ISOTOPES, 1992, 43 (11) : 1383 - 1385
  • [47] C-11
    JEWETT, D
    CHEMTECH, 1992, 22 (10) : 592 - 596
  • [48] SYNTHESIS OF C-11 LABELED (R)-CARNITINE
    HOLSCHBACH, M
    HAMKENS, W
    RODEN, W
    FEINENDEGEN, LE
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1991, 29 (05): : 599 - 606
  • [49] SYNTHESIS AND BRAIN UPTAKE OF C-11 PHENETHYLAMINE
    JAY, M
    DIGENIS, GA
    CHANEY, JE
    WASHBURN, LC
    BYRD, BL
    HAYES, RL
    CALLAHAN, AP
    JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1981, 18 (1-2): : 237 - 237
  • [50] THE PREPARATION OF A C-11 LABELED NEUROHORMONE - [C-11] MELATONIN
    LEBARS, D
    LUTHRA, SK
    PIKE, VW
    DUC, CL
    APPLIED RADIATION AND ISOTOPES, 1987, 38 (12) : 1073 - 1077
12345