SYNTHESIS AND BIOLOGICAL-ACTIVITY OF TETRACYCLIC CARBAPENEMS

被引：14
|
作者：
SCHMIDT, G [1 ]
SCHROCK, W [1 ]
ENDERMANN, R [1 ]
机构：
[1] BAYER AG,INST CHEMOTHERAPY,W-5600 WUPPERTAL 1,GERMANY
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期
关键词：
D O I：
10.1016/S0960-894X(01)80924-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and biological activity of new tetracyclic carbapenem antibiotics 15, 16 and 17 are described. Pharmacokinetic studies in the mouse have shown the pivaloyloxymethyl ester prodrug 18 to have oral activity.
引用
收藏
页码：2193 / 2198
页数：6
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