SYNTHESIS AND BIOLOGICAL-ACTIVITY OF TETRACYCLIC CARBAPENEMS

被引：14
|
作者：
SCHMIDT, G [1 ]
SCHROCK, W [1 ]
ENDERMANN, R [1 ]
机构：
[1] BAYER AG,INST CHEMOTHERAPY,W-5600 WUPPERTAL 1,GERMANY
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期
关键词：
D O I：
10.1016/S0960-894X(01)80924-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis and biological activity of new tetracyclic carbapenem antibiotics 15, 16 and 17 are described. Pharmacokinetic studies in the mouse have shown the pivaloyloxymethyl ester prodrug 18 to have oral activity.
引用
收藏
页码：2193 / 2198
页数：6
相关论文
共 50 条
  • [21] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF POLYCYCLIC QUINONES
    TOLSTIKOV, GA
    SHULTZ, EE
    TOLSTIKOVA, TG
    SIBIRSKII KHIMICHESKII ZHURNAL, 1992, (04): : 24 - 31
  • [22] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF ZOAPATANOL ANALOGS
    WANI, MC
    VISHNUVAJJALA, BR
    SWAIN, WE
    RECTOR, DH
    COOK, CE
    PETROW, V
    REEL, JR
    ALLEN, KM
    LEVINE, SG
    JOURNAL OF MEDICINAL CHEMISTRY, 1983, 26 (03) : 426 - 430
  • [23] FLUORINATED ANTHRACYCLINES - SYNTHESIS AND BIOLOGICAL-ACTIVITY
    TONKIN, KC
    BROWNLEE, RTC
    ZUNINO, F
    PHILLIPS, DR
    INVESTIGATIONAL NEW DRUGS, 1990, 8 (01) : 1 - 6
  • [24] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF SINEFUNGIN ANALOGS
    BLANCHARD, P
    DODIC, N
    FOURREY, JL
    LAWRENCE, F
    MOUNA, AM
    ROBERTGERO, M
    JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (09) : 2798 - 2803
  • [25] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF AMIDINE SULFIDES
    PANDEYA, SN
    RAM, P
    CURRENT SCIENCE, 1978, 47 (19): : 722 - 726
  • [26] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF DIGITOXIGENIN AMINOESTERS
    VALCAVI, U
    CAPONI, R
    CORSI, B
    INNOCENTI, S
    MARTELLI, P
    MINOJA, F
    FARMACO-EDIZIONE SCIENTIFICA, 1981, 36 (11): : 971 - 982
  • [27] NOVEL HETEROAROTINOIDS - SYNTHESIS AND BIOLOGICAL-ACTIVITY
    SPRUCE, LW
    GALE, JB
    BERLIN, KD
    VERMA, AK
    BREITMAN, TR
    JI, XH
    VANDERHELM, D
    JOURNAL OF MEDICINAL CHEMISTRY, 1991, 34 (01) : 430 - 439
  • [28] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF NOVEL INDOLYLIMIDAZOLINONES
    TRIVEDI, B
    SHAH, VH
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1993, 70 (07) : 645 - 646
  • [29] THE SYNTHESIS AND BIOLOGICAL-ACTIVITY OF GLYCOSIDASE INHIBITORS
    NISHIMURA, Y
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 1991, 49 (09) : 846 - 863
  • [30] SYNTHESIS AND BIOLOGICAL-ACTIVITY OF DANSYL THYMIDINES
    BONORA, GM
    PALU, G
    DOSSANTOS, C
    BIASOLO, MA
    MELONI, GA
    FARMACO, 1989, 44 (10): : 951 - 958
12345