HUMULON, A BITTER IN THE HOP, INHIBITS TUMOR PROMOTION BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE IN 2-STAGE CARCINOGENESIS IN MOUSE SKIN

被引：0
|
作者：
YASUKAWA, K [1 ]
TAKEUCHI, M [1 ]
TAKIDO, M [1 ]
机构：
[1] INST MICROBIAL CHEM,TOKYO 141,JAPAN
来源：
ONCOLOGY | 1995年 / 52卷 / 02期
关键词：
HOP; HUMULUS LUPULUS; BITTER; HUMULON; INHIBITION OF TUMOR PROMOTION; 12-O-TETRADECANOYLPHORBOL-13-ACETATE; ANTI-INFLAMMATION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Humulon, one of the bitters in the hop, was isolated from the female flowers of Humulus lupulus. This component has inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. At 1 mg/mouse, humulon inhibited markedly the tumor-promoting effect of TPA (1 mu g/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 mu g/mouse). Furthermore, humulon inhibited arachidonic acid-induced inflammatory ear edema in mice.
引用
收藏
页码：156 / 158
页数：3
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