HUMULON, A BITTER IN THE HOP, INHIBITS TUMOR PROMOTION BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE IN 2-STAGE CARCINOGENESIS IN MOUSE SKIN

被引：0
|
作者：
YASUKAWA, K [1 ]
TAKEUCHI, M [1 ]
TAKIDO, M [1 ]
机构：
[1] INST MICROBIAL CHEM,TOKYO 141,JAPAN
来源：
ONCOLOGY | 1995年 / 52卷 / 02期
关键词：
HOP; HUMULUS LUPULUS; BITTER; HUMULON; INHIBITION OF TUMOR PROMOTION; 12-O-TETRADECANOYLPHORBOL-13-ACETATE; ANTI-INFLAMMATION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Humulon, one of the bitters in the hop, was isolated from the female flowers of Humulus lupulus. This component has inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. At 1 mg/mouse, humulon inhibited markedly the tumor-promoting effect of TPA (1 mu g/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[a]anthracene (50 mu g/mouse). Furthermore, humulon inhibited arachidonic acid-induced inflammatory ear edema in mice.
引用
收藏
页码：156 / 158
页数：3
相关论文
共 50 条
  • [31] Inhibitory effect of Pruni Cortex extract and its component, octacosyl ferulate, on tumour promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin
    Yasukawa, K
    Dimitrijevic, SM
    Evans, FJ
    Kawabata, S
    Takido, M
    PHYTOTHERAPY RESEARCH, 1998, 12 (04) : 261 - 265
  • [32] Inhibitory effect of euphol, a triterpene alcohol from the roots of Euphorbia kansui, on tumour promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin
    Yasukawa, K
    Akihisa, T
    Yoshida, ZY
    Takido, M
    JOURNAL OF PHARMACY AND PHARMACOLOGY, 2000, 52 (01) : 119 - 124
  • [33] Evaluation of pentacyclic triterpenes found in Perilla frutescens for inhibition of skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
    Cho, Jiyoon
    Tremmel, Lisa
    Rho, Okkyung
    Camelio, Andrew M.
    Siegel, Dionicio
    Slaga, Thomas J.
    DiGiovanni, John
    ONCOTARGET, 2015, 6 (36) : 39292 - 39306
  • [34] INHIBITORY EFFECT OF CURCUMIN, CHLOROGENIC ACID, CAFFEIC ACID, AND FERULIC ACID ON TUMOR PROMOTION IN MOUSE SKIN BY 12-O-TETRADECANOYLPHORBOL-13-ACETATE
    HUANG, MT
    SMART, RC
    WONG, CQ
    CONNEY, AH
    CANCER RESEARCH, 1988, 48 (21) : 5941 - 5946
  • [35] Association of a murine chromosome 9 locus (Psl1) with susceptibility to mouse skin tumor promotion by 12-O-tetradecanoylphorbol-13-acetate
    Angel, JM
    Beltran, L
    Minda, K
    Rupp, T
    DiGiovanni, J
    MOLECULAR CARCINOGENESIS, 1997, 20 (02) : 162 - 167
  • [36] SYNERGISTIC INTERACTION BETWEEN THE NONPHORBOL ESTER-TYPE PROMOTER MIREX AND 12-O-TETRADECANOYLPHORBOL-13-ACETATE IN MOUSE SKIN TUMOR PROMOTION
    MEYER, SA
    KIM, TW
    MOSER, GJ
    MONTEIRORIVIERE, NA
    SMART, RC
    CARCINOGENESIS, 1994, 15 (01) : 47 - 52
  • [37] Auraptene, a citrus coumarin, inhibits 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion in ICR mouse skin.
    Murakami, A
    Kuki, W
    Takahashi, Y
    Yonei, H
    Nakamura, Y
    Ohto, Y
    Ohigashi, H
    Koshimizu, K
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 213 : 154 - AGFD
  • [38] MOUSE SKIN INFLAMMATION INDUCED BY MULTIPLE TOPICAL APPLICATIONS OF 12-O-TETRADECANOYLPHORBOL-13-ACETATE
    STANLEY, PL
    STEINER, S
    HAVENS, M
    TRAMPOSCH, KM
    SKIN PHARMACOLOGY, 1991, 4 (04): : 262 - 271
  • [39] EFFECTS OF SHORT-TERM EXPOSURE TO THE TUMOR PROMOTER, 12-O-TETRADECANOYLPHORBOL-13-ACETATE ON SKIN CARCINOGENESIS IN SENCAR MICE
    DIWAN, BA
    WARD, JM
    HENNEMAN, J
    WENK, ML
    CANCER LETTERS, 1985, 26 (02) : 177 - 184
  • [40] KERATIN GENE-EXPRESSION IN MOUSE SKIN TUMORS AND IN MOUSE SKIN TREATED WITH 12-O-TETRADECANOYLPHORBOL-13-ACETATE
    TOFTGARD, R
    YUSPA, SH
    ROOP, DR
    CANCER RESEARCH, 1985, 45 (11) : 5845 - 5850
12345