Synthesis and biological studies of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d] thiazol-2-yl)-7-(4-chlorophenyl)pyrido-[2,3-d]-pyrimidin-4(3H)-one derivatives

被引：0
|
作者：
Suresh, M. [1 ]
Lavanya, P. [2 ]
Raju, K. Naga [2 ]
Jonnalagadda, Sreekanth B. [1 ]
Rao, C. Venkata [2 ]
机构：
[1] Univ KwaZulu Natal, Sch Chem, ZA-4000 Durban, South Africa
[2] Sri Venkateswara Univ, Coll Sci, Dept Chem, Tirupati 517502, Andhra Prades, India
来源：
ORGANIC COMMUNICATIONS | 2011年 / 4卷 / 02期
关键词：
2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d] thiazol-2-yl)-7-(4-chlorophenyl)pyrido[2,3-d]-pyrimidin-4(3H)-one; antibacterial; antifungal;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A series of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d]thiazol-2-yl)-7-(4-chlorophenyl) pyrido[2,3-d]pyrimidin-4(3H)-one derivatives were synthesized and evaluated for their antibacterial and antifungal activity. All the derivatives were efficiently synthesized in four steps. The structure of the newly synthesized compounds was elucidated by their IR, H-1-NMR, C-13 NMR, LCMS mass spectra and elemental analysis.
引用
收藏
页码：33 / 41
页数：9
相关论文
共 50 条
  • [31] Derivatives of the condensed thieno[2,3-d]pyrimidines.: 20.: Synthesis of 2-substituted 5,6-dihydro-8H-pyrano[4′,3′:4,5]thieno[2,3-d]pyrimidin-4(3H)-ones and 5,6,7,8-tetrahydrobenzo[b]thieno[2,3-d]pyrimidin-4(3H)-ones
    Mkrtchyan, AP
    Noravyan, AS
    KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII, 2006, (03): : 441 - 444
  • [32] Synthesis and Antibacterial and Antifungal Activity of New Thieno[2,3-d]Pyrimidin-4(3H)-One Derivatives
    Kahveci, B.
    Dogan, I. S.
    Mentese, E.
    Sellitepe, H. E.
    Kart, D.
    PHARMACEUTICAL CHEMISTRY JOURNAL, 2020, 54 (06) : 647 - 653
  • [33] 2-(4-Chloro-3-methylphenoxy)-3-(4-chlorophenyl)5-methyl-8,9,10,11-tetrahydro-1-benzothieno[2′,3′:2,3]pyrido[4,3-d]pyrimidin-4(3H)-one dichloromethane solvate
    Liu, JC
    He, HW
    Ding, MW
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2005, 61 : O3686 - O3687
  • [34] Synthesis and mycobacterial evaluation of 5-substituted-6-acetyl-2-amino-7-methyl-5,8-dihydropyrido-[2,3-d]pyrimidin-4(3H)-one derivatives
    Agre, Neha
    Degani, Mariam
    Gupta, Antima
    Bhakta, Sanjib
    Ray, Mukti Kanta
    ARCHIV DER PHARMAZIE, 2019, 352 (09)
  • [35] 3-(4-Chlorophenyl)-2-(diisopropylamino)1-benzofuro[3,2-d]pyrimidin-4(3H)-one
    Liao, Quan-Bin
    Li, Gui-Hua
    Zhu, Zheng-Rong
    Liu, Ming-Guo
    ACTA CRYSTALLOGRAPHICA SECTION E-STRUCTURE REPORTS ONLINE, 2008, 64 : O13 - U2598
  • [36] Anticancer Activity Evaluation of New Thieno[2,3-d]pyrimidin-4(3H)-ones and Thieno[3,2-d]pyrimidin-4(3H)-one Derivatives
    Shyyka, Olga
    Pokhodylo, Nazariy
    Finiuk, Nataliya
    Matiychuk, Vasyl
    Stoika, Rostyslav
    Obushak, Mykola
    SCIENTIA PHARMACEUTICA, 2018, 86 (03)
  • [37] A facile synthesis of 2-substituted thieno[3′,2′-5,6]-pyrido[4,3-d]pyrimidin-4(3H)-ones
    Liu, Jian-Chao
    He, Hong-Wu
    Ren, Qing-Yun
    Ding, Ming-Wu
    JOURNAL OF HETEROCYCLIC CHEMISTRY, 2006, 43 (03) : 803 - 806
  • [38] Enaminonitrile as Building Block in Heterocyclic Synthesis: Synthesis of Novel 4H-Furo[2,3-d][1,3] oxazin-4-one and Furo[2,3-d] pyrimidin-4(3H)-one Derivatives
    El-Shahawi, Manal M.
    El-Ziaty, Ahmed K.
    JOURNAL OF CHEMISTRY, 2017, 2017
  • [39] 3-(4-Chlorophenyl)-5-methyl-2-propylamino-8,9,10,11-tetrahydro-2-benzothieno[2′,3′;2,3]-pyrido[4,5-d]pyrimidin-4(3H)-one
    Liu, JC
    Chen, HL
    Chen, T
    He, HW
    Ding, MW
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2005, 61 : O3187 - O3189
  • [40] Synthesis and Characterization of New 2-Methoxy-thieno[2,3-d]pyrimidin-4(3H)-one
    Lu, Lian-Ying
    Yu, Zhong-Shan
    Fang, Zheng-Dong
    Chen, Yong-Zhou
    Zhou, Wen
    Wei, Xian-Hong
    Tao, Qing
    ADVANCES IN CHEMICAL ENGINEERING II, PTS 1-4, 2012, 550-553 : 89 - 92
12345