C-14 AND H-3 LABELING OF STIRIPENTOL, 4,4-DIMETHYL-1-(3,4-METHYLENEDIOXYPHENYL)-1-PENTEN-3-OL

被引：3
|
作者：
MADELMONT, JC
DUPUY, JM
RAPP, M
LABARRE, P
MAURIZIS, JC
LEPAGE, F
VEYRE, A
机构：
[1] CTR JEAN PERRIN,F-63011 CLERMONT FERRAND,FRANCE
[2] FAC MED CLERMONT,BIOPHYS MED LAB,F-63001 CLERMONT FERRAND,FRANCE
[3] LABS BIOCODEX,F-60200 COMPIEGNE,FRANCE
来源：
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1992年 / 31卷 / 11期
关键词：
D O I：
10.1002/jlcr.2580311116
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
4,4-dimethyl-1-(3,4-methylenedioxyphenyl)-1-pentene-3-ol or stiripentol was labelled by C-14 and H-3. C-14 labelling was performed on the carbone 1 of the pentene group via a four steps procedure after the carbonatation. The radiochemical yield calculated from the precursor ((BaCO3)-C-14 is 28 %. H-3 labelling was performed on the position 3 of the pentene chain by reduction of the corresponding cetone via NaBT4. The radiochemical yield calculated from the precursor (NaBT4) is 40 %.
引用
收藏
页码：961 / 966
页数：6
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