RESPONSE OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS TO INTERLEUKIN-1 IN THE AGING RAT

被引：0
|
作者：
BERNARDINI, R
MAUCERI, G
IURATO, MP
CHIARENZA, A
LEMPEREUR, L
SCAPAGNINI, U
机构：
来源：
PROGRESS IN NEUROENDOCRINIMMUNOLOGY | 1992年 / 5卷 / 03期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Plasma ACTH levels after intravenous i.v. injection of IL-1alpha (IL-1) were measured in 2- and 24-month-old Sprague-Dawley rats. Blood samples were withdrawn at -30, 0, 30, 60, 90 and 120 min after IL-1 injection. In addition, the effects of IL-1 and serotonin (5-HT) on in vitro CRH secretion and content in hypothalami from 2- and 24-month-old rats were investigated. IL-1 injection stimulated ACTH secretion in a dose-related manner, in both 2- and 24-month-old rats. The peak of the effect occurred 60 min after the injection. ACTH levels returned to baseline within 120 min in 2-month-old rats. Plasma ACTH levels in untreated 24-month-old rats returned to baseline 240 min after injection. In vitro incubation of rat hypothalami with either IL-1 or 5-HT at equimolar concentrations resulted in the stimulation of immunoreactive CRH (iCRH) secretion from both 2- and 24-month-old hypothalami. However, the iCRH content in the latter was increased vs. basal if compared to 2-month-old rats. These results suggest the feedback between IL-1 and the hypothalamic-pituitary-adrenal axis is altered during aging.
引用
收藏
页码：166 / 171
页数：6
相关论文
共 50 条
  • [41] Suicide and the hypothalamic-pituitary-adrenal axis
    Young, EA
    Coryell, W
    LANCET, 2005, 366 (9490): : 959 - 961
  • [42] PRENATAL ALCOHOL EXPOSURE ALTERS THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS RESPONSE OF IMMATURE OFFSPRING TO INTERLEUKIN-1 - IS NITRIC-OXIDE INVOLVED
    LEE, S
    RIVIER, C
    ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1994, 18 (05) : 1242 - 1247
  • [43] Methamphetamine and the hypothalamic-pituitary-adrenal axis
    Zuloaga, Damian G.
    Jacobskind, Jason S.
    Raber, Jacob
    FRONTIERS IN NEUROSCIENCE, 2015, 9 : 178
  • [44] The Hypothalamic-Pituitary-Adrenal Axis and the Fetus
    Morsi, Amr
    DeFranco, Donald
    Witchel, Selma F.
    HORMONE RESEARCH IN PAEDIATRICS, 2018, 89 (05): : 380 - 387
  • [45] HYPOTHALAMIC-PITUITARY-ADRENAL AXIS FUNCTION IN THE ZUCKER OBESE RAT
    PLOTSKY, PM
    THRIVIKRAMAN, KV
    WATTS, AG
    HAUGER, RL
    ENDOCRINOLOGY, 1992, 130 (04) : 1931 - 1941
  • [46] PHARMACOLOGICAL REGULATION OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS ACTIVITY IN RAT
    Spiga, F.
    JOURNAL OF PSYCHOPHARMACOLOGY, 2010, 24 : A87 - A87
  • [47] Effects of halothane and methoxyflurane on the hypothalamic-pituitary-adrenal axis in rat
    Karuri, AR
    Engelking, LR
    Kumar, MSA
    BRAIN RESEARCH BULLETIN, 1998, 47 (03) : 205 - 209
  • [48] IMIPRAMINE EFFECT ON HYPOTHALAMIC-PITUITARY-ADRENAL AXIS RESPONSE TO HYPOGLYCEMIA
    KATHOL, RG
    JAECKLE, R
    WYSHAM, C
    SHERMAN, BM
    PSYCHIATRY RESEARCH, 1992, 41 (01) : 45 - 52
  • [49] HEMIDECORTICATION AND THE RESPONSE OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS TO STRESS IN RATS
    GOUVEIA, EM
    COVIAN, MR
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 1981, 14 (4-5) : 342 - 342
  • [50] Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress
    Heiman, ML
    Ahima, RS
    Craft, LS
    Schoner, B
    Stephens, TW
    Flier, JS
    ENDOCRINOLOGY, 1997, 138 (09) : 3859 - 3863
12345