RESPONSE OF THE HYPOTHALAMIC-PITUITARY-ADRENAL AXIS TO INTERLEUKIN-1 IN THE AGING RAT

被引：0
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作者：
BERNARDINI, R
MAUCERI, G
IURATO, MP
CHIARENZA, A
LEMPEREUR, L
SCAPAGNINI, U
机构：
来源：
PROGRESS IN NEUROENDOCRINIMMUNOLOGY | 1992年 / 5卷 / 03期
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R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Plasma ACTH levels after intravenous i.v. injection of IL-1alpha (IL-1) were measured in 2- and 24-month-old Sprague-Dawley rats. Blood samples were withdrawn at -30, 0, 30, 60, 90 and 120 min after IL-1 injection. In addition, the effects of IL-1 and serotonin (5-HT) on in vitro CRH secretion and content in hypothalami from 2- and 24-month-old rats were investigated. IL-1 injection stimulated ACTH secretion in a dose-related manner, in both 2- and 24-month-old rats. The peak of the effect occurred 60 min after the injection. ACTH levels returned to baseline within 120 min in 2-month-old rats. Plasma ACTH levels in untreated 24-month-old rats returned to baseline 240 min after injection. In vitro incubation of rat hypothalami with either IL-1 or 5-HT at equimolar concentrations resulted in the stimulation of immunoreactive CRH (iCRH) secretion from both 2- and 24-month-old hypothalami. However, the iCRH content in the latter was increased vs. basal if compared to 2-month-old rats. These results suggest the feedback between IL-1 and the hypothalamic-pituitary-adrenal axis is altered during aging.
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页码：166 / 171
页数：6
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