HIV-INHIBITORY NATURAL-PRODUCTS .11. COMPARATIVE-STUDIES OF SULFATED STEROLS FROM MARINE-INVERTEBRATES

被引：65

作者：

MCKEE, TC ^{[1
]}

CARDELLINA, JH ^{[1
]}

RICCIO, R ^{[1
]}

DAURIA, MV ^{[1
]}

IORIZZI, M ^{[1
]}

MINALE, L ^{[1
]}

MORAN, RA ^{[1
]}

GULAKOWSKI, RJ ^{[1
]}

MCMAHON, JB ^{[1
]}

BUCKHEIT, RW ^{[1
]}

SNADER, KM ^{[1
]}

BOYD, MR ^{[1
]}

机构：

[1] NCI,DIV CANC TREATMENT,DEV THERAPEUT PROGRAM,DRUG DISCOVERY RES & DEV LAB,BLDG 1052,ROOM 121,FREDERICK,MD 21702

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1994年 / 37卷 / 06期

关键词：

D O I：

10.1021/jm00032a012

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A total of 22 sulfated sterols isolated from marine sponges, ophiuroids (brittle stars), and asteroids (sea stars) were comparatively evaluated for their antiviral activity against HIV-1 and HIV-2. In general, sterols with sulfate groups at position 2, 3, or 6 were the most active, with EC50 values- of 3-13 muM against HIV-1 (RF) and 2-8 muM against HIV-2 (CBL20). Those compounds which were sulfated on the sterol D ring were completely inactive against both HIV-1 and HIV-2. Overall, sulfated sterols active against HIV-1 were also active against HIV-2.

引用

页码：793 / 797

页数：5

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