GLOMERULOPRESSIN PRODUCTION BY ISOLATED RAT-LIVER AFTER AMINO-ACID INFUSION

被引：0
|
作者：
SILBERSTEIN, C [1 ]
BRANDARIZ, S [1 ]
ARTEMAN, P [1 ]
AGUIRRE, J [1 ]
URANGA, J [1 ]
DELCASTILLO, E [1 ]
机构：
[1] INST BIOL & MED EXPTL, VUELTA OBLIGADO 2490, RA-1428 BUENOS AIRES, DF, ARGENTINA
来源：
PROCEEDINGS OF THE SOCIETY FOR EXPERIMENTAL BIOLOGY AND MEDICINE | 1991年 / 198卷 / 01期
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D O I：
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中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The infusion of certain amino acids, such as serine, alanine, and proline (SAP), has been shown to increase the glomerular filtration rate, whereas branched chain amino acids (BCAA) leucine, isoleucine, and valine fail to modify the glomerular filtration rate. It has been suggested that this effect of amino acids on the glomerular filtration rate is mediated by the action of the hormone glomerulopressin. The purpose of this work was to study the action of SAP and BCAA on glomerulopressin production. Livers isolated from rats were perfused with (i) Krebs-Ringer-Bicarbonate, (ii) SAP, or (iii) BCAA. Results indicate that glomerulopressin production is stimulated by SAP, but inhibited by BCAA.
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页码：625 / 628
页数：4
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