Prophylaxis against Recurrence in Liver Transplantation Patients with Hepatitis B Virus: What is New?

被引：6

作者：

Harmanci, Ozgur ^{[1
]}

Selcuk, Haldun ^{[1
]}

Haberal, Mehmet ^{[2
]}

机构：

[1] Baskent Univ, Med Sch, Dept Gastroenterol, Maresal Fevzi Cakmak Cad 45 Bahcelievler, TR-06490 Ankara, Turkey

[2] Baskent Univ, Med Sch, Dept Gen Surg, Ankara, Turkey

来源：

JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY | 2014年 / 2卷 / 04期

关键词：

Hepatitis B virus; Liver transplantation; Recurrence; Prophylaxis;

D O I：

10.14218/JCTH.2014.00023

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Hepatitis B virus (HBV) causes an endemic infection that affects nearly 2 billion patients worldwide. It is one of the leading causes of liver cirrhosis, hepatocellular carcinoma (HCC), and liver transplantation (LT). Recurrence of HBV infection after LT is due to specific HBV-host genome interactions. Although hepatitis B immunoglobulin treatment constituted the backbone of HBV recurrence, use of the nucleoside and nucleotide analogs (especially the ones with a higher genetic barrier to resistance), either alone or in combination, offer us new and powerful options in overcoming this serious issue. (C) 2014 The Second Affiliated Hospital of Chongqing Medical University. Published by XIA & HE Publishing Ltd. All rights reserved.

引用

页码：259 / 265

页数：7

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