MONITORING AND CONTROL OF BIOTECHNOLOGICAL PRODUCTION PROCESSES BY BIO-FET-FIA-SENSORS

被引：21

作者：

BRAND, U ^{[1
]}

BRANDES, L ^{[1
]}

KOCH, V ^{[1
]}

KULLIK, T ^{[1
]}

REINHARDT, B ^{[1
]}

RUTHER, F ^{[1
]}

SCHEPER, T ^{[1
]}

SCHUGERL, K ^{[1
]}

WANG, S ^{[1
]}

WU, X ^{[1
]}

FERRETTI, R ^{[1
]}

PRASAD, S ^{[1
]}

WILHELM, D ^{[1
]}

机构：

[1] UNIV HANNOVER,INST HALBLEITERTECHNOL & WERKSTOFFE ELEKTROTECH,W-3000 HANNOVER,GERMANY

来源：

APPLIED MICROBIOLOGY AND BIOTECHNOLOGY | 1991年 / 36卷 / 02期

关键词：

D O I：

10.1007/BF00164414

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Single and multisensor field effect transistors (FET) with a pH-sensitive Si/SiO2/Si3N4/Ta2O5-gate and reference electrode (for single sensor) were developed and used for manufacturing the following biological (Bio)-FETs: for glucose analysis, glucose oxidase-FET (GOD-FET); for urea analysis, urease-FET; and for cephalosporin C analysis, cephalosporinase-FET. The GOD-FETs were integrated into flow injection analysis (FIA) of the Eppendorf variables analyser (EVA) system and used for monitoring the glucose concentration in microbial cultivation and production processes with recombinant Escherichia coli K12 MF, recombinant E. coli JM103, Saccharomyces cerevisiae H620, and Candida boidinii. Urease-FET-FIA was used to monitor the urea concentration in a simulated cultivation of Cephalosporium acremonium and urease-FET-FIA and GOD-FET-FIA for the monitoring of urea and glucose concentrations in simulated S. cerevisiae cultivations.

引用

页码：167 / 172

页数：6

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