INFLUENCE OF AGE ON THE PHARMACOKINETICS OF ALFENTANIL - GENDER DEPENDENCE

被引：53
|
作者：
LEMMENS, HJM
BURM, AGL
HENNIS, PJ
GLADINES, MPPR
BOVILL, JG
机构：
[1] Department of Anesthesiology, University Hospital Leiden, Leiden, 2300 RC
来源：
CLINICAL PHARMACOKINETICS | 1990年 / 19卷 / 05期
关键词：
D O I：
10.2165/00003088-199019050-00005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Studies on the effects of age on the pharmacokinetics of alfentanil are inconclusive. A possible factor in explaining the differences between various studies could be the effect of gender. The authors studied the effects of age on the pharmacokinetics of alfentanil in female (n = 21) and male (n = 15) patients undergoing lower abdominal surgery under nitrous oxide alfentanil anaesthesia. There was a significant negative correlation (r = −0.79, p < 0.001) between plasma alfentanil clearance (CL) and age in women (<50y, median CL 24.84 L/h; >50y, median CL 14.52 L/h), but not in men (<50y, median CL 19.44 L/h; >50y, median CL 16.2 L/h). The conclusion is drawn that the effects of age on the pharmacokinetics of alfentanil are gender-dependent. © 1990, Adis International Limited. All rights reserved.
引用
收藏
页码：416 / 422
页数：7
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